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Complement Activati...
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
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- Berg, Aase (author)
- Stavanger University Hospital, Norway ; University of Bergen, Norway
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- Otterdal, Karl (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Patel, Sam (author)
- Central Hospital of Maputo, Mozambique
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- Gonca, Miguel (author)
- Central Hospital of Maputo, Mozambique
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- David, Catarina (author)
- Central Hospital of Maputo, Mozambique
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- Dalen, Ingvild (author)
- Stavanger University Hospital, Norway
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- Nymo, Stig (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Nilsson, Margareta (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Nordling, Sofia (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Magnusson,Uppsala University
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- Magnusson, Peetra (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Magnusson,Uppsala University
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- Ueland, Thor (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Prato, Mauro (author)
- University of Torino, Italy
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- Giribaldi, Giuliana (author)
- University of Torino, Italy
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- Mollnes, Tom Eirik (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Aukrust, Pål (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Langeland, Nina (author)
- University of Bergen, Norway
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- Nilsson, Per H., 1980- (author)
- Oslo University Hospital Rikshospitalet, Norway
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(creator_code:org_t)
- 2015-05-15
- 2015
- English.
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In: The Internet Journal of Infectious Diseases. - : Oxford University Press (OUP). - 1528-8366 .- 0022-1899 .- 1537-6613. ; 212:11, s. 1835-1840
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Abstract
Subject headings
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- The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients with confirmed Plasmodium falciparum malaria and in human whole-blood specimens stimulated with malaria-relevant agents ex vivo. Complement was significantly activated in the malaria cohort, compared with healthy controls, and was positively correlated with disease severity and with certain cytokines, in particular interleukin 8 (IL-8)/CXCL8. This was confirmed in ex vivo-stimulated blood specimens, in which complement inhibition significantly reduced IL-8/CXCL8 release. P. falciparum malaria is associated with systemic complement activation and complement-dependent release of inflammatory cytokines, of which IL-8/CXCL8 is particularly prominent.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- C5a/C5aR1; IL-8/CXCL8; Plasmodium falciparum; complement activation; cytokines; heme; hemozoin; inflammation; malaria
- Immunologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Berg, Aase
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Otterdal, Karl
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Patel, Sam
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Gonca, Miguel
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David, Catarina
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Dalen, Ingvild
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Nymo, Stig
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Nilsson, Margare ...
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Nordling, Sofia
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Magnusson, Peetr ...
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Ueland, Thor
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Prato, Mauro
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Giribaldi, Giuli ...
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Mollnes, Tom Eir ...
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Aukrust, Pål
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Langeland, Nina
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Nilsson, Per H., ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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The Internet Jou ...
- By the university
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Uppsala University
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Linnaeus University