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Altered proteins in...
Altered proteins in the aging brain
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- Elobeid, Adila (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Libard, Sylwia (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Leino, Marina (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Popova, Svetlana (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Alafuzoff, Irina (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
- 2016-03-15
- 2016
- English.
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In: Journal of Neuropathology and Experimental Neurology. - : Oxford University Press. - 0022-3069 .- 1554-6578. ; 75:4, s. 316-325
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Abstract
Subject headings
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- We assessed the prevalence of common altered brain proteins in 296 cognitively unimpaired subjects ranging from age 50 to 102 years. The incidence and the stage of hyperphosphorylated-tau (HP tau), beta-amyloid, alpha-synuclein (alpha S), and transactive response DNA (TDP) binding protein 43 (TDP43)-immunoreactivity (-IR) increased with age. HP tau-IR was observed in 98% of the subjects; the locus coeruleus was solely affected in 46%, and 79% of the subjects were in Braak stages a to II. beta-Amyloid was seen in 47% of subjects and the Thal phase correlated with the HP tau Braak stage and age. Intermediate Alzheimer disease-related pathology (ADRP) was seen in 12%; 52% of the subjects with HP tau-IR fulfilled criteria for definite primary age-related tauopathy (PART). The incidence of concomitant pathology (alpha S, TDP43) did not differ between those with PART and those with ADRP but the former were younger. TDP43-IR was observed in 36%; the most frequently affected region was the medulla; alpha S-IR was observed in 19% of subjects. In 41% of the subjects from 80 to 89 years at death, 3 altered proteins were seen in the brain. Thus, altered proteins are common in the brains of cognitively unimpaired aged subjects; this should be considered while developing diagnostic biomarkers, particularly for identifying subjects at early stages of neurodegenerative diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- alpha-Synuclein; beta-Amyloid; Aging; Cognition; Hyperphosphorylated-tau; Immunohistochemistry; Transactive response DNA binding protein 43
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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