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Antibacterial effec...
Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum
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- Gomaa, Mohamed N. (author)
- King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia.
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- Soliman, Kawther (author)
- King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia.
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- Ayesh, Ahmed (author)
- King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia.
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- Abd El-Wahed, Aida (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Hamza, Zeinab (author)
- Natl Res Ctr, Food Toxins & Contaminants Dept, Marine Toxins Lab, Cairo, Egypt.
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- Mansour, Hager M. (author)
- Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan.
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- Khalifa, Shaden A. M. (author)
- Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden.
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- Mohd Ali, Hapipah Bint (author)
- Univ Malaya, Dept Chem, Ctr Nat Prod & Drug Discovery CENAR, Fac Sci, Kuala Lumpur 50603, Malaysia.
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- El-Seedi, Hesham R. (author)
- Uppsala universitet,Avdelningen för farmakognosi,Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden.;Univ Malaya, Dept Chem, Ctr Nat Prod & Drug Discovery CENAR, Fac Sci, Kuala Lumpur 50603, Malaysia.
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King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia Avdelningen för farmakognosi (creator_code:org_t)
- 2015-07-17
- 2016
- English.
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In: Natural Product Research. - : Informa UK Limited. - 1478-6419 .- 1478-6427. ; 30:6, s. 729-734
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound anti-microbial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- soft coral
- Sarcophyton trocheliophorum
- terpenoid
- in vitro
- antimicrobial assays
Publication and Content Type
- ref (subject category)
- art (subject category)
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