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Therapeutic Hypothe...
Therapeutic Hypothermia for the Treatment of Acute Myocardial Infarction-Combined Analysis of the RAPID MI-ICE and the CHILL-MI Trials
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- Erlinge, David (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Götberg, Matthias (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Noc, Marko (author)
- Ctr Intens Internal Med, Ljubljana, Slovenia.
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- Lang, Irene (author)
- Med Univ Vienna, Dept Cardiol, Vienna, Austria.;Med Univ Vienna, Dept Emergency Med, Vienna, Austria.
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- Holzer, Michael (author)
- Med Univ Vienna, Dept Cardiol, Vienna, Austria.;Med Univ Vienna, Dept Emergency Med, Vienna, Austria.
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- Clemmensen, Peter (author)
- Nykoebing F Hosp, Dept Cardiol, Nykoebing F, Denmark.
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- Jensen, Ulf (author)
- Karolinska Univ Hosp, Dept Med, Cardiol Unit, Stockholm, Sweden.
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- Metzler, Bernhard (author)
- Univ Hosp Internal Med, Dept Cardiol, Innsbruck, Austria.
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- James, Stefan K. (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Botker, Hans Erik (author)
- Aarhus Univ Hosp Skejby, Dept Cardiol, Aarhus, Denmark.
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- Omerovic, Elmir, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Koul, Sasha (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Engblom, Henrik (author)
- Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Psychol, S-22185 Lund, Sweden.
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- Carlsson, Marcus (author)
- Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Psychol, S-22185 Lund, Sweden.
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- Arheden, Håkan (author)
- Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Psychol, S-22185 Lund, Sweden.
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- Östlund, Ollie (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Klos, Bradley (author)
- Philips Healthcare, San Diego, CA USA.
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- Harnek, Jan (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Cardiol, Clin Sci, S-22185 Lund, Sweden.
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- Olivecrona, Göran (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Nykoebing F Hosp, Dept Cardiol, Nykoebing F, Denmark.
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2015
- 2015
- English.
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In: Therapeutic Hypothermia and Temperature Management. - : Mary Ann Liebert Inc. - 2153-7658 .- 2153-7933. ; 5:2, s. 77-84
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- In the randomized rapid intravascular cooling in myocardial infarction as adjunctive to percutaneous coronary intervention (RAPID MI-ICE) and rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction CHILL-MI studies, hypothermia was rapidly induced in conscious patients with ST-elevation myocardial infarction (STEMI) by a combination of cold saline and endovascular cooling. Twenty patients in RAPID MI-ICE and 120 in CHILL-MI with large STEMIs, scheduled for primary percutaneous coronary intervention (PCI) within <6 hours after symptom onset were randomized to hypothermia induced by rapid infusion of 600-2000mL cold saline combined with endovascular cooling or standard of care. Hypothermia was initiated before PCI and continued for 1-3 hours after reperfusion aiming at a target temperature of 33 degrees C. The primary endpoint was myocardial infarct size (IS) as a percentage of myocardium at risk (IS/MaR) assessed by cardiac magnetic resonance imaging at 4 +/- 2 days. Patients randomized to hypothermia treatment achieved a mean core body temperature of 34.7 degrees C before reperfusion. Although significance was not achieved in CHILL-MI, in the pooled analysis IS/MaR was reduced in the hypothermia group, relative reduction (RR) 15% (40.5, 28.0-57.6 vs. 46.6, 36.8-63.8, p=0.046, median, interquartile range [IQR]). IS/MaR was predominantly reduced in early anterior STEMI (0-4h) in the hypothermia group, RR=31% (40.5, 28.8-51.9 vs. 59.0, 45.0-67.8, p=0.01, median, IQR). There was no mortality in either group. The incidence of heart failure was reduced in the hypothermia group (2 vs. 11, p=0.009). Patients with large MaR (>30% of the left ventricle) exhibited significantly reduced IS/MaR in the hypothermia group (40.5, 27.0-57.6 vs. 55.1, 41.1-64.4, median, IQR; hypothermia n=42 vs. control n=37, p=0.03), while patients with MaR<30% did not show effect of hypothermia (35.8, 28.3-57.5 vs. 38.4, 27.4-59.7, median, IQR; hypothermia n=15 vs. control n=19, p=0.50). The prespecified pooled analysis of RAPID MI-ICE and CHILL-MI indicates a reduction of myocardial IS and reduction in heart failure by 1-3 hours with endovascular cooling in association with primary PCI of acute STEMI predominantly in patients with large area of myocardium at risk. (ClinicalTrials.gov id NCT00417638 and NCT01379261).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Erlinge, David
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Götberg, Matthia ...
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Noc, Marko
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Lang, Irene
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Holzer, Michael
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Clemmensen, Pete ...
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Jensen, Ulf
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Metzler, Bernhar ...
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James, Stefan K.
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Botker, Hans Eri ...
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Omerovic, Elmir, ...
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Koul, Sasha
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Engblom, Henrik
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Carlsson, Marcus
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Arheden, Håkan
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Östlund, Ollie
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Wallentin, Lars
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Klos, Bradley
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Harnek, Jan
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Olivecrona, Göra ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Therapeutic Hypo ...
- By the university
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Uppsala University
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Lund University
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University of Gothenburg