Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO.

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MARC

den Hoed, Marcel (author)

Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO.

Article/chapterEnglish2009

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Elsevier BV,2009
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LIBRIS-ID:oai:DiVA.org:uu-278391
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-278391URI
https://doi.org/10.3945/ajcn.2009.28053DOI

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Language:English
Summary in:English

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BACKGROUND: The common rs9939609 single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is associated with adiposity, possibly by affecting satiety responsiveness.OBJECTIVE: The objective was to determine whether postprandial responses in hunger and satiety are associated with rs9939609, taking interactions with other relevant candidate genes into account.DESIGN: Sixty-two women and 41 men [age: 31 +/- 14 y; body mass index (in kg/m(2)): 25.0 +/- 3.1] were genotyped for 5 SNPs in FTO, DNMT1, DNMT3B, LEP, and LEPR. Individuals received fixed meals provided in energy balance. Hunger and satiety were determined pre- and postprandially by using visual analog scales.RESULTS: A general association test showed a significant association between postprandial responses in hunger and satiety with rs9939609 (P = 0.036 and P = 0.050, respectively). Individuals with low postprandial responses in hunger and satiety were overrepresented among TA/AA carriers in rs9939609 (FTO) compared with TT carriers (dominant and additive model: P = 0.013 and P = 0.020, respectively). Moreover, multifactor dimensionality reduction showed significant epistatic interactions for the postprandial decrease in hunger involving rs9939609 (FTO), rs992472 (DNMT3B), and rs1137101 (LEPR). Individuals with a low postprandial decrease in hunger were overrepresented among TA/AA (dominant), CC/CA (recessive), and AG/GG (dominant) carriers in rs9939609 (FTO), rs992472 (DNMT3B), and rs1137101 (LEPR), respectively (n = 39), compared with TT, AA, and/or AA carriers in these SNPs, respectively (P = 0.00001). Each SNP had an additional effect.CONCLUSIONS: Our results confirm a role for FTO in responsiveness to hunger and satiety cues in adults in an experimental setting. The epistatic interaction suggests that DNA methylation, an epigenetic process, affects appetite.

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Westerterp-Plantenga, Margriet S (author)
Bouwman, Freek G (author)
Mariman, Edwin C M (author)
Westerterp, Klaas R (author)

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In:American Journal of Clinical Nutrition: Elsevier BV90:50002-91651938-3207

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