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Infants born large-...
Infants born large-for-gestational-age display slower growth in early infancy, but no epigenetic changes at birth
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- Chiavaroli, Valentina (author)
- Uppsala universitet,Forskargrupper (Inst. för kvinnors och barns hälsa),Liggins Institute, University of Auckland, Auckland, New Zealand
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- Cutfield, Wayne S (author)
- Liggins Institute, University of Auckland, Auckland, New Zealand
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- Derraik, José G. B. (author)
- Liggins Institute, University of Auckland, Auckland, New Zealand
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- Pan, Zengxiang (author)
- Liggins Institute, University of Auckland, Auckland, New Zealand
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- Ngo, Sherry (author)
- Liggins Institute, University of Auckland, Auckland, New Zealand
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- Sheppard, Allan (author)
- Liggins Institute, University of Auckland, Auckland, New Zealand
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- Craigie, Susan (author)
- Liggins Institute, University of Auckland, Auckland, New Zealand
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- Stone, Peter (author)
- Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
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- Sadler, Lynn (author)
- National Women's Health, Auckland District Health Board, Auckland, New Zealand
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- Ahlsson, Fredrik (author)
- Liggins Institute, University of Auckland, New Zealand
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Uppsala universitet Forskargrupper (Inst för kvinnors och barns hälsa) (creator_code:org_t)
- 2015-09-30
- 2015
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Abstract
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- We evaluated the growth patterns of infants born large-for-gestational-age (LGA) from birth to age 1 year compared to those born appropriate-for-gestational-age (AGA). In addition, we investigated possible epigenetic changes associated with being born LGA. Seventy-one newborns were classified by birth weight as AGA (10(th)-90(th) percentile; n = 42) or LGA (>90(th) percentile; n = 29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Genome-wide DNA methylation was analysed on umbilical tissue in 19 AGA and 27 LGA infants. At birth, LGA infants had greater weight (p < 0.0001), length (p < 0.0001), ponderal index (p = 0.020), as well as greater head (p < 0.0001), chest (p = 0.044), and abdominal (p = 0.007) circumferences than AGA newborns. LGA infants were still larger at the age of 3 months, but by age 6 months there were no more differences between groups, due to higher length and weight increments in AGA infants between 0 and 6 months (p < 0.0001 and p = 0.002, respectively). Genome-wide analysis showed no epigenetic differences between LGA and AGA infants. Overall, LGA infants had slower growth in early infancy, being anthropometrically similar to AGA infants by 6 months of age. In addition, differences between AGA and LGA newborns were not associated with epigenetic changes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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Chiavaroli, Vale ...
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Cutfield, Wayne ...
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Derraik, José G. ...
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Pan, Zengxiang
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Ngo, Sherry
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Sheppard, Allan
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show more...
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Craigie, Susan
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Stone, Peter
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Sadler, Lynn
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Ahlsson, Fredrik
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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Uppsala University