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Comorbidity of Cogn...
Comorbidity of Cognitive Impairment and Late-Life Depression Increase Mortality : Results From a Cohort of Community-Dwelling Elderly Individuals in Rural Greece
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Georgakis, Marios K (author)
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- Papadopoulos, Fotios C (author)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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Protogerou, Athanasios D (author)
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Pagonari, Ioanna (author)
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Sarigianni, Fani (author)
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Biniaris-Georgallis, Stylianos-Iason (author)
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Kalogirou, Eleni I (author)
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Thomopoulos, Thomas P (author)
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Kapaki, Elisabeth (author)
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Papageorgiou, Charalampos (author)
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Papageorgiou, Socratis G (author)
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Tousoulis, Dimitrios (author)
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Petridou, Eleni Th (author)
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(creator_code:org_t)
- 2016-02-25
- 2016
- English.
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In: Journal of Geriatric Psychiatry and Neurology. - : SAGE Publications. - 0891-9887 .- 1552-5708. ; 29:4, s. 195-204
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: To investigate the association of cognitive impairment (COGI) and depression with all-cause mortality and cardiovascular-specific mortality among community-dwelling elderly individuals in rural Greece.METHODS: Cognition and depressive symptomatology of 676 Velestino town residents aged ≥60 years were assessed using Mini-Mental State Examination (MMSE) and Geriatric Depression Scale (GDS), respectively. Eight-year all-cause mortality and cardiovascular mortality were explored by multivariate Cox regression models controlling for major confounders.RESULTS: Two hundred and one patients died during follow-up. Cognitive impairment (MMSE ≤ 23) was independently associated with all-cause mortality (hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.13-2.18) and cardiovascular mortality (HR: 1.57, 95%CI: 1.03-2.41). Moderate to severe depression (GDS > 10) was significantly associated only with a 51% increase in all-cause mortality. A male-specific association was noted for moderate to severe depression, whereas the effect of COGI was limited to females. Noteworthy, COGI and depression comorbidity, rather than their sole presence, increased all-cause mortality and cardiovascular mortality by 66% and 72%, respectively. The mortality effect of COGI was augmented among patients with depression and of depression among patients with COGI.CONCLUSION: COGI and depression, 2 entities often coexisting among elderly individuals, appear to increase all-cause mortality and cardiovascular mortality. Gender-specific modes may prevail but their comorbidity should be carefully assessed, as it seems to represent an independent index of increased frailty, which eventually shortens life expectancy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- cognitive impairment; dementia; depression; elderly; survival; mortality
Publication and Content Type
- ref (subject category)
- art (subject category)
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Georgakis, Mario ...
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Papadopoulos, Fo ...
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Protogerou, Atha ...
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Pagonari, Ioanna
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Sarigianni, Fani
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Biniaris-Georgal ...
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Kalogirou, Eleni ...
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Thomopoulos, Tho ...
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Kapaki, Elisabet ...
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Papageorgiou, Ch ...
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Papageorgiou, So ...
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Tousoulis, Dimit ...
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Petridou, Eleni ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Journal of Geria ...
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Uppsala University