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Folate and B12 seru...
Folate and B12 serum levels in association with depression in the aged : a systematic review and meta-analysis
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- Petridou, Eleni Th. (author)
- Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
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- Kousoulis, Antonis A. (author)
- Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
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- Michelakos, Theodoros (author)
- Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
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- Papathoma, Paraskevi (author)
- Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
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- Dessypris, Nick (author)
- Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
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- Papadopoulos, Fotios C. (author)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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- Stefanadis, Christodoulos (author)
- Univ Athens, Sch Med, Hippokrat Hosp, Dept Cardiol 1, Athens, Greece
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(creator_code:org_t)
- 2015-06-08
- 2016
- English.
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In: Aging & Mental Health. - : Informa UK Limited. - 1360-7863 .- 1364-6915. ; 20:9, s. 965-973
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVES: To systematically review and meta-analyse existing evidence on the association between folate/B12, and depression among the aged people.METHODS: Following PRISMA/STROBE guidelines, the Medline abstracts were retrieved using an algorithm comprising relevant MeSH terms. Publications on the association of folate/B12 serum measurements with depression were abstracted independently by two reviewers and included in both gender and gender-specific meta-analyses, following recarculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies.RESULTS: Both gender data were contributed by 11 folate-related (7949 individuals) and 9 B12-related studies (6308 individuals), whereas gender-specific data by 4 folate-related (3409 individuals) and 3 B12-related studies (1934 individuals). A statistically significant overall association between both exposures of interest (low folate and B12 levels) and depression was observed (ORfolate:1.23, 95%CI:1.07-1.43, ORB12:1.20, 95%CI:1.02-1.42). Gender-specific estimates pointed to a statistically significant positive association between low B12 levels and depression only among women (OR:1.33, 95%CI:1.02-1.74); the gender specific associations of low folate levels with depression were, however, non-significant and of counter-direction (ORfemales:1.37, 95%CI:0.90-2.07; ORmales:0.84, 95%CI:0.57-1.25).CONCLUSION: Low folate and B12 serum levels seem to be associated with depression in the aged. The gender-specific analyses are confined to a positive association of low B12 with depression among older women and call for further research in this direction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- folate; vitamin B12; depression; meta-analysis; gender; geriatric
Publication and Content Type
- ref (subject category)
- art (subject category)
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