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Definition of noctu...
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Emilsson, Össur IngiUppsala universitet,Lung- allergi- och sömnforskning,Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.
(author)
Definition of nocturnal gastroesophageal reflux for studies on respiratory diseases
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-01-29
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Informa UK Limited,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-279545
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-279545URI
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https://doi.org/10.3109/00365521.2015.1124284DOI
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https://lup.lub.lu.se/record/8572880URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objective Nocturnal gastroesophageal reflux (nGER) has been associated with respiratory diseases. Our aim was to study a questionnaire method to identify nGER subjects with respiratory involvement in a general population. Material and methods A subgroup of Icelandic participants in the European Community Respiratory Health Survey III (ECRHS III) reporting symptoms of nGER (n =48) as well as age and gender paired controls (n =42) were studied further by a structured interview, questionnaires, laryngeal fibrescopy, and exhaled breath condensate. A subgroup underwent 24-h oesophageal pH impedance (24-h MII-pH) measurements. Symptoms of nGER were assessed with a modified version of the reflux disease questionnaire (RDQ), where symptoms were divided into daytime and nocturnal. A report of nGER both at baseline and at follow-up was defined as persistent nGER. Results Participants reporting persistent nGER had significantly more signs of laryngopharyngeal reflux according to the reflux finding score than those without nGER (Mean +/- SD: 5.1 +/- 2.3 vs. 3.9 +/- 2.2, p =0.02). Of the 16 persistent nGER subjects that underwent 24-h MII-pH, 11 had abnormal gastroesophageal reflux, but none of three control subjects (69% vs. 0%). Pepsin was more commonly found in exhaled breath condensate in the nGER group (67% vs. 45%, p =0.04). Conclusions Participants with nGER symptoms at least once a month, reported on two occasions, had a high level of positive 24-h MII-pH measurements, laryngeal inflammation and pepsin in exhaled breath condensate. This nGER definition identified a representable group for studies on nGER and respiratory diseases in a general population.
Subject headings and genre
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Benediktsdottir, BryndisUniv Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.
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Olafsson, IsleifurLandspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland.
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Cook, ElizabethLandspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland.
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Juliusson, SigurdurUniv Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Ear Nose & Throat, Reykjavik, Iceland.
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Berg, SörenLund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Otolaryngol & Head & Neck Surg, Lund, Sweden.(Swepub:lu)so5081be
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Nordang, LeifUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)lenor499
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Björnsson, Einar StefanUniv Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Gastroenterol, Reykjavik, Iceland.
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Gudlaugsdottir, SunnaLandspitali Univ Hosp, Dept Gastroenterol, Reykjavik, Iceland.
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Gudmundsdottir, Anna SoffiaLandspitali Univ Hosp, Dept Gastroenterol, Reykjavik, Iceland.
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
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Gislason, ThorarinnUniv Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.
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Uppsala universitetLung- allergi- och sömnforskning
(creator_code:org_t)
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In:Scandinavian Journal of Gastroenterology: Informa UK Limited51:5, s. 524-5300036-55211502-7708
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