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Resting-State Bra i...
Resting-State Bra in and the FTO Obesity Risk Allele : Default Mode, Sensorimotor, and Salience Network Connectivity Underlying Different Somatosensory Integration and Reward Processing between Genotypes
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- Olivo, Gaia (author)
- Uppsala universitet,Funktionell farmakologi
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- Wiemerslage, Lyle (author)
- Uppsala universitet,Funktionell farmakologi
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- Nilsson, Emil K. (author)
- Uppsala universitet,Funktionell farmakologi
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- Dahlberg, Linda Solstrand (author)
- Uppsala universitet,Funktionell farmakologi
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- Larsen, Anna L. (author)
- Uppsala universitet,Funktionell farmakologi
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- Bucaro, Marcela Olaya (author)
- Uppsala universitet,Funktionell farmakologi
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- Gustafsson, Veronica P. (author)
- Uppsala universitet,Funktionell farmakologi
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- Titova, Olga E. (author)
- Uppsala universitet,Funktionell farmakologi
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- Bandstein, Marcus (author)
- Uppsala universitet,Funktionell farmakologi
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- Larsson, Elna-Marie (author)
- Uppsala universitet,Radiologi
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- Benedict, Christian (author)
- Uppsala universitet,Funktionell farmakologi
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- Brooks, Samantha J. (author)
- Uppsala universitet,Funktionell farmakologi,Univ Cape Town, Dept Psychiat, ZA-7925 Cape Town, South Africa.
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- Schioth, Helgi B. (author)
- Uppsala universitet,Funktionell farmakologi
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(creator_code:org_t)
- 2016-02-17
- 2016
- English.
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In: Frontiers in Human Neuroscience. - : Frontiers Media SA. - 1662-5161. ; 10
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Abstract
Subject headings
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- Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene are linked to obesity, but how these SNPs influence resting-state neural activation is unknown. Few brain-imaging studies have investigated the influence of obesity-related SNPs on neural activity, and no study has investigated resting-state connectivity patterns. We tested connectivity within three, main resting-state networks: default mode (DMN), sensorimotor (SMN), and salience network (SN) in 30 male participants, grouped based on genotype for the rs9939609 FTO SNP, as well as punishment and reward sensitivity measured by the Behavioral Inhibition (BIS) and Behavioral Activation System (BAS) questionnaires. Because obesity is associated with anomalies in both systems, we calculated a BIS/BAS ratio (BBr) accounting for features of both scores. A prominence of BIS over BAS (higher BBr) resulted in increased connectivity in frontal and paralimbic regions. These alterations were more evident in the obesity-associated AA genotype, where a high BBr was also associated with increased SN connectivity in dopaminergic circuitries, and in a subnetwork involved in somatosensory integration regarding food. Participants with AA genotype and high BBr, compared to corresponding participants in the TT genotype, also showed greater DMN connectivity in regions involved in the processing of food cues, and in the SMN for regions involved in visceral perception and reward-based learning. These findings suggest that neural connectivity patterns influence the sensitivity toward punishment and reward more closely in the AA carriers, predisposing them to developing obesity. Our work explains a complex interaction between genetics, neural patterns, and behavioral measures in determining the risk for obesity and may help develop individually-tailored strategies for obesity prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- FTO
- resting-state
- MRI
- obesity
- SNP
- default mode network
- salience network
- sensorimotor network
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Olivo, Gaia
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Wiemerslage, Lyl ...
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Nilsson, Emil K.
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Dahlberg, Linda ...
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Larsen, Anna L.
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Bucaro, Marcela ...
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show more...
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Gustafsson, Vero ...
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Titova, Olga E.
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Bandstein, Marcu ...
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Larsson, Elna-Ma ...
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Benedict, Christ ...
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Brooks, Samantha ...
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Schioth, Helgi B ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Frontiers in Hum ...
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Uppsala University