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Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding
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- Newman, Joseph A. (author)
- Univ Oxford, ORCRB, Struct Genom Consortium, Roosevelt Dr, Oxford OX3 7DQ, England.
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- Cooper, Christopher D. O. (author)
- Univ Oxford, ORCRB, Struct Genom Consortium, Roosevelt Dr, Oxford OX3 7DQ, England.;Univ Huddersfield, Sch Appl Sci, Dept Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England.
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- Roos, Anette K. (author)
- Uppsala universitet,Struktur- och molekylärbiologi,Univ Oxford, ORCRB, Struct Genom Consortium, Roosevelt Dr, Oxford OX3 7DQ, England.
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- Univ Oxford, ORCRB, Struct Genom Consortium, Roosevelt Dr, Oxford OX3 7DQ, England Univ Oxford, ORCRB, Struct Genom Consortium, Roosevelt Dr, Oxford OX3 7DQ, England.;Univ Huddersfield, Sch Appl Sci, Dept Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England. (creator_code:org_t)
- 2016-02-24
- 2016
- English.
- In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:2
- Journal article (peer-reviewed)
Abstract
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- The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, making them an attractive target for the development of targeted and immunotherapeutic cancer treatments. Some MAGE proteins are thought to play an active role in driving cancer, modulating the activity of E3 ubiquitin ligases on targets related to apoptosis. Here we determined the crystal structures of MAGE-A3 and MAGE-A4. Both proteins crystallized with a terminal peptide bound in a deep cleft between two tandem-arranged winged helix domains. MAGE-A3 (but not MAGE-A4), is predominantly dimeric in solution. Comparison of MAGE-A3 and MAGE-A3 with a structure of an effector-bound MAGE-G1 suggests that a major conformational rearrangement is required for binding, and that this conformational plasticitymay be targeted by allosteric binders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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