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PET-CT for staging ...
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Barrington, Sally FKing's College London
(author)
PET-CT for staging and early response : results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study.
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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American Society of Hematology,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-282631
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282631URI
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https://doi.org/10.1182/blood-2015-11-679407DOI
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https://lup.lub.lu.se/record/8592550URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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International guidelines recommend that positron emission tomography-computed tomography (PET-CT) should replace CT in Hodgkin lymphoma (HL). The aims of this study were to compare PET-CT with CT for staging and measure agreement between expert and local readers, using a 5-point scale (Deauville criteria), to adapt treatment in a clinical trial: Response-Adapted Therapy in Advanced Hodgkin Lymphoma (RATHL). Patients were staged using clinical assessment, CT, and bone marrow biopsy (RATHL stage). PET-CT was performed at baseline (PET0) and after 2 chemotherapy cycles (PET2) in a response-adapted design. PET-CT was reported centrally by experts at 5 national core laboratories. Local readers optionally scored PET2 scans. The RATHL and PET-CT stages were compared. Agreement among experts and between expert and local readers was measured. RATHL and PET0 stage were concordant in 938 (80%) patients. PET-CT upstaged 159 (14%) and downstaged 74 (6%) patients. Upstaging by extranodal disease in bone marrow (92), lung (11), or multiple sites (12) on PET-CT accounted for most discrepancies. Follow-up of discrepant findings confirmed the PET characterization of lesions in the vast majority. Five patients were upstaged by marrow biopsy and 7 by contrast-enhanced CT in the bowel and/or liver or spleen. PET2 agreement among experts (140 scans) with a κ (95% confidence interval) of 0.84 (0.76-0.91) was very good and between experts and local readers (300 scans) at 0.77 (0.68-0.86) was good. These results confirm PET-CT as the modern standard for staging HL and that response assessment using Deauville criteria is robust, enabling translation of RATHL results into clinical practice.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kirkwood, Amy AUniversity College London
(author)
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Franceschetto, AntonellaUniversity of Modena and Reggio Emilia
(author)
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Fulham, Michael JRoyal Prince Alfred Hospital
(author)
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Roberts, Thomas HUniversity College London
(author)
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Almquist, HelénLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)extLU-691
(author)
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Brun, EvaLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ebr
(author)
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Hjorthaug, KarinAarhus University Hospital
(author)
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Viney, Zaid NGuy's and St Thomas' NHS Foundation Trust
(author)
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Pike, Lucy CKing's College London
(author)
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Federico, MassimoUniversity of Modena and Reggio Emilia
(author)
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Luminari, StefanoUniversity of Modena and Reggio Emilia
(author)
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Radford, John
(author)
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Trotman, Judith
(author)
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Fosså, Alexander
(author)
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Berkahn, Leanne
(author)
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Molin, DanielUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)danimoli
(author)
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D'Amore, Francesco
(author)
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Sinclair, Donald A
(author)
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Smith, Paul
(author)
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O'Doherty, Michael J
(author)
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Stevens, Lindsey
(author)
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Johnson, Peter W
(author)
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King's College LondonUniversity College London
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology127:12, s. 1531-15380006-49711528-0020
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Barrington, Sall ...
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Kirkwood, Amy A
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Franceschetto, A ...
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Fulham, Michael ...
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Roberts, Thomas ...
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Almquist, Helén
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Brun, Eva
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Hjorthaug, Karin
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Viney, Zaid N
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Pike, Lucy C
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Federico, Massim ...
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Luminari, Stefan ...
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Radford, John
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Trotman, Judith
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Fosså, Alexander
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Berkahn, Leanne
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Molin, Daniel
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D'Amore, Frances ...
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Sinclair, Donald ...
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Smith, Paul
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O'Doherty, Micha ...
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Stevens, Lindsey
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Johnson, Peter W
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