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AtHESPERIN :
AtHESPERIN : a novel regulator of circadian rhythms with poly(A)-degrading activity in plants
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- Delis, Costas (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.;TEI Peloponnese, Kalamata, Greece.
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- Krokida, Afrodite (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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- Tomatsidou, Anastasia (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.;Univ Crete, Dept Biol, Iraklion, Greece.
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- Tsikou, Daniela (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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- Beta, Rafailia A. A. (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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- Tsioumpekou, Maria (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning,Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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- Moustaka, Julietta (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.;Aristotle Univ Thessaloniki, Dept Bot, Thessaloniki, Greece.
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- Stravodimos, Georgios (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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- Leonidas, Demetres D. (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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- Balatsos, Nikolaos A. A. (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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- Papadopoulou, Kalliope K. (author)
- Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece.
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Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece;TEI Peloponnese, Kalamata, Greece. Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece. (creator_code:org_t)
- 2015-11-30
- 2016
- English.
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In: RNA Biology. - : Informa UK Limited. - 1547-6286 .- 1555-8584. ; 13:1, s. 68-82
- Related links:
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https://www.tandfonl...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We report the identification and characterization of a novel gene, AtHesperin (AtHESP) that codes for a deadenylase in Arabidopsis thaliana. The gene is under circadian clock-gene regulation and has similarity to the mammalian Nocturnin. AtHESP can efficiently degrade poly(A) substrates exhibiting allosteric kinetics. Size exclusion chromatography and native electrophoresis coupled with kinetic analysis support that the native enzyme is oligomeric with at least 3 binding sites. Knockdown and overexpression of AtHESP in plant lines affects the expression and rhythmicity of the clock core oscillator genes TOC1 and CCA1. This study demonstrates an evolutionary conserved poly(A)-degrading activity in plants and suggests deadenylation as a mechanism involved in the regulation of the circadian clock. A role of AtHESP in stress response in plants is also depicted.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- nocturnin
- Arabidopsis
- Allosteric
- circadian
- RNA stability
- deadenylation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Delis, Costas
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Krokida, Afrodit ...
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Tomatsidou, Anas ...
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Tsikou, Daniela
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Beta, Rafailia A ...
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Tsioumpekou, Mar ...
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show more...
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Moustaka, Juliet ...
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Stravodimos, Geo ...
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Leonidas, Demetr ...
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Balatsos, Nikola ...
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Papadopoulou, Ka ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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RNA Biology
- By the university
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Uppsala University