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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06615naa a2200649 4500 | |
| 001 | oai:DiVA.org:uu-282787 | |
| 003 | SwePub | |
| 008 | 160407s2016 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:68fb1fba-7708-460e-b2b5-6b601fedf1c3 | |
| 009 | oai:prod.swepub.kib.ki.se:133123253 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2827872 URI |
| 024 | 7 | a https://doi.org/10.1007/s00125-015-3852-92 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/85924682 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1331232532 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gillberg, Linnu Rigshosp, Dept Endocrinol, Sect 7652,Tagensvej 20, DK-2200 Copenhagen N, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.,Copenhagen University Hospital4 aut |
| 245 | 1 0 | a Adipose tissue transcriptomics and epigenomics in low birthweight men and controls :b role of high-fat overfeeding |
| 264 | c 2016-01-11 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 338 | a print2 rdacarrier | |
| 520 | a Aims/hypothesis Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW. Methods mRNA expression was analysed using Affymetrix Human Gene 1.0 ST arrays and DNA methylation using Illumina 450K BeadChip arrays. Results We found differential DNA methylation at 53 sites in SAT from LBW vs normal birthweight (NBW) men (false discovery rate < 5%), including sites in the FADS2 and CPLX1 genes previously associated with type 2 diabetes. When we used reference-free cell mixture adjustments to potentially adjust for cell composition, 4,323 sites had differential methylation in LBW vs NBW men. However, no differences in SAT gene expression levels were identified between LBW and NBW men. In the combined group of all 40 participants, 3,276 genes (16.5%) were differentially expressed in SAT after HFO (false discovery rate < 5%) and there was no difference between LBW men and controls. The most strongly upregulated genes were ELOVL6, FADS2 and NNAT; in contrast, INSR, IRS2 and the SLC27A2 fatty acid transporter showed decreased expression after HFO. Interestingly, SLC27A2 expression correlated negatively with diabetes- and obesity-related traits in a replication cohort of 142 individuals. DNA methylation at 652 CpG sites (including in CDK5, IGFBP5 and SLC2A4) was altered in SAT after overfeeding in this and in another cohort. Conclusions/interpretation Young men who had a LBW exhibit epigenetic alterations in their adipose tissue that potentially influence insulin resistance and risk of type 2 diabetes. Short-term overfeeding influences gene transcription and, to some extent, DNA methylation in adipose tissue; there was no major difference in this response between LBW and control participants. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Diet | |
| 653 | a Epigenetics | |
| 653 | a Gene expression | |
| 653 | a High-fat overfeeding | |
| 653 | a Low birthweight | |
| 653 | a Metabolism | |
| 653 | a Obesity | |
| 653 | a Type 2 diabetes | |
| 700 | 1 | a Perfilyev, Alexanderu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)med-apy |
| 700 | 1 | a Brons, Charlotteu Rigshosp, Dept Endocrinol, Sect 7652,Tagensvej 20, DK-2200 Copenhagen N, Denmark.,Copenhagen University Hospital4 aut |
| 700 | 1 | a Thomasen, Martinu Rigshosp, Dept Endocrinol, Sect 7652,Tagensvej 20, DK-2200 Copenhagen N, Denmark.,Copenhagen University Hospital4 aut |
| 700 | 1 | a Grunnet, Louise G.u Rigshosp, Dept Endocrinol, Sect 7652,Tagensvej 20, DK-2200 Copenhagen N, Denmark.,Copenhagen University Hospital4 aut |
| 700 | 1 | a Volkov, Petru Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)med-pvo |
| 700 | 1 | a Rosqvist, Fredriku Uppsala University,Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)frero353 |
| 700 | 1 | a Iggman, Davidu Uppsala University,Uppsala universitet,Centrum för klinisk forskning Dalarna4 aut0 (Swepub:uu)davig338 |
| 700 | 1 | a Dahlman, Ingridu Karolinska Institutet4 aut |
| 700 | 1 | a Risérus, Ulfu Uppsala University,Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser |
| 700 | 1 | a Rönn, Tinau Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)med-tar |
| 700 | 1 | a Nilsson, Emma Au Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-eca |
| 700 | 1 | a Vaag, Allanu Rigshosp, Dept Endocrinol, Sect 7652,Tagensvej 20, DK-2200 Copenhagen N, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.,Copenhagen University Hospital4 aut |
| 700 | 1 | a Ling, Charlotteu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-cl0 |
| 710 | 2 | a Rigshosp, Dept Endocrinol, Sect 7652,Tagensvej 20, DK-2200 Copenhagen N, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.b Copenhagen University Hospital4 org |
| 773 | 0 | t Diabetologiad : Springer Science and Business Media LLCg 59:4, s. 799-812q 59:4<799-812x 0012-186Xx 1432-0428 |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00125-015-3852-9.pdf |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26750116?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1007/s00125-015-3852-9y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282787 |
| 856 | 4 8 | u https://doi.org/10.1007/s00125-015-3852-9 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/8592468 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133123253 |
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