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Tissue Response to ...
Tissue Response to Subcutaneously Implanted Recombinant Spider Silk : An in Vivo Study
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- Fredriksson, Camilla (author)
- Linköpings universitet,Hand och plastikkirurgi,Hälsouniversitetet,Berzelius Clinical Research Center, Berzelius Science Park, Linköping, Sweden
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- Hedhammar, My (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, the Biomedical Centre, Uppsala, Sweden
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- Feinstein, Ricardo (author)
- National Veterinary Institute, Uppsala, Sweden
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- Nordling, Kerstin (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, the Biomedical Centre, Uppsala, Sweden
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- Kratz, Gunnar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hand och plastikkirurgi,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken med brännskadeenheten
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- Johansson, Jan (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, the Biomedical Centre, Uppsala, Sweden
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- Huss, Fredrik, 1971- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Brännskadevård,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken med brännskadeenheten
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- Rising, Anna (author)
- Karolinska Institutet,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, the Biomedical Centre, Uppsala, Sweden
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(creator_code:org_t)
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- 2009-11-20
- 2009
- English.
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In: Materials. - Basel, Switzerland : MDPI AG. - 1996-1944. ; 2:4, s. 1908-1922
- Related links:
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https://www.mdpi.com...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://res.slu.se/i...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Spider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms macroscopic fibres in physiological solution was developed. Herein, 4RepCT and MersilkTM (control) fibres were implanted subcutaneously in rats for seven days, without any negative systemic or local reactions. The tissue response, characterised by infiltration of macrophages and multinucleated cells, was similar with both fibres, while only the 4RepCT-fibres supported ingrowth of fibroblasts and newly formed capillaries. This in vivo study indicates that 4RepCT-fibres are well tolerated and could be used for medical applications, e.g., tissue engineering.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
Keyword
- spider silk
- recombinant
- biocompatibility
- in vivo
- Plastic Surgery
- Plastikkirurgi
Publication and Content Type
- ref (subject category)
- art (subject category)
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