Search: onr:"swepub:oai:DiVA.org:uu-287143" >
Mechanotransduction...
Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
-
Elsevier BV,2012
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-287143
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-287143URI
-
https://doi.org/10.1016/j.devcel.2011.12.020DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Lymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early lymphatic-valve morphogenesis and the role of biomechanical forces are not well understood. We found that the transcription factors PROX1 and FOXC2, highly expressed from the onset of valve formation, mediate segregation of lymphatic-valve-forming cells and cell mechanosensory responses to shear stress in vitro. Mechanistically, PROX1, FOXC2, and flow coordinately control expression of the gap junction protein connexin37 and activation of calcineurin/NFAT signaling. Connexin37 and calcineurin are required for the assembly and delimitation of lymphatic valve territory during development and for its postnatal maintenance. We propose a model in which regionally increased levels/activation states of transcription factors cooperate with mechanotransduction to induce a discrete cell-signaling pattern and morphogenetic event, such as formation of lymphatic valves. Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Agalarov, Yan
(author)
-
Maby-El Hajjami, Hélène
(author)
-
Jaquet, Muriel
(author)
-
Hägerling, René
(author)
-
Pollmann, Cathrin
(author)
-
Bebber, Damien
(author)
-
Pfenniger, Anna
(author)
-
Miura, Naoyuki
(author)
-
Dormond, Olivier
(author)
-
Calmes, Jean-Marie
(author)
-
Adams, Ralf H
(author)
-
Mäkinen, Taija
(author)
-
Kiefer, Friedemann
(author)
-
Kwak, Brenda R
(author)
-
Petrova, Tatiana V
(author)
Related titles
-
In:Developmental Cell: Elsevier BV22:21534-58071878-1551
Internet link
Find in a library
To the university's database
- By the author/editor
-
Sabine, Amélie
-
Agalarov, Yan
-
Maby-El Hajjami, ...
-
Jaquet, Muriel
-
Hägerling, René
-
Pollmann, Cathri ...
-
show more...
-
Bebber, Damien
-
Pfenniger, Anna
-
Miura, Naoyuki
-
Dormond, Olivier
-
Calmes, Jean-Mar ...
-
Adams, Ralf H
-
Mäkinen, Taija
-
Kiefer, Friedema ...
-
Kwak, Brenda R
-
Petrova, Tatiana ...
-
show less...
- Articles in the publication
-
Developmental Ce ...
- By the university
-
Uppsala University