Search: onr:"swepub:oai:DiVA.org:uu-292995" >
Diagnostic and prog...
Diagnostic and prognostic implications using age- and gender-specific cut-offs for high-sensitivity cardiac troponin T - Sub-analysis from the TRAPID-AMI study
-
- Mueller-Hennessen, Matthias (author)
- Univ Heidelberg Hosp, Dept Internal Med Cardiol Angiol & Pulmonol 3, Heidelberg, Germany.
-
- Lindahl, Bertil (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
- Giannitsis, Evangelos (author)
- Univ Heidelberg Hosp, Dept Internal Med Cardiol Angiol & Pulmonol 3, Heidelberg, Germany.
-
show more...
-
- Biener, Moritz (author)
- Univ Heidelberg Hosp, Dept Internal Med Cardiol Angiol & Pulmonol 3, Heidelberg, Germany.
-
- Vafaie, Mehrshad (author)
- Univ Heidelberg Hosp, Dept Internal Med Cardiol Angiol & Pulmonol 3, Heidelberg, Germany.
-
- deFilippi, Christopher R. (author)
- Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA.
-
- Christ, Michael (author)
- Paracelsus Med Univ, Dept Emergency & Crit Care Med, Community Hosp, Nurnberg, Germany.
-
- Santalo-Bel, Miguel (author)
- Hosp Santa Creu & Sant Pau, Semicrit Unit, Barcelona, Spain.;Inst Invest Biomed St Pau, Barcelona, Spain.
-
- Panteghini, Mauro (author)
- Univ Milan, Sch Med, Dept Biomed & Clin Sci Luigi Sacco, Milan, Italy.
-
- Plebani, Mario (author)
- Univ Hosp Padova, Dept Lab Med, Padua, Italy.
-
- Verschuren, Franck (author)
- Catholic Univ Louvain, Dept Acute Med, Clin Univ St Luc, B-1200 Brussels, Belgium.
-
- Jernberg, Tomas (author)
- Karolinska Institutet
-
- French, John K. (author)
- Univ New S Wales, Liverpool Hosp, Sydney, NSW, Australia.
-
- Christenson, Robert H. (author)
- Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA.
-
- Body, Richard (author)
- Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England.
-
- McCord, James (author)
- Henry Ford Hlth Syst, Henry Ford Heart & Vasc Inst, Detroit, MI USA.
-
- Dilba, Peter (author)
- Roche Diagnost Germany, Penzberg, Germany.
-
- Katus, Hugo A. (author)
- Univ Heidelberg Hosp, Dept Internal Med Cardiol Angiol & Pulmonol 3, Heidelberg, Germany.
-
- Mueller, Christian (author)
- Univ Basel Hosp, Cardiol & Cardiovasc Res Inst Basel, Basel, Switzerland.
-
show less...
-
Univ Heidelberg Hosp, Dept Internal Med Cardiol Angiol & Pulmonol 3, Heidelberg, Germany Kardiologi (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
-
In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 209, s. 26-33
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Objectives: To evaluate the impact of age-and gender-specific cut-offs for high-sensitivity cardiac troponin T (hs-cTnT) compared to the general 99th percentile hs-cTnT cut-off on diagnosis and prognosis of acute myocardial infarction (AMI).Methods: 1282 unselected patients presenting to the emergency department with suspected AMI were enrolled as part of the TRAPID-AMI study. In the present sub-analysis, reclassification of AMI diagnosis was performed by comparing the general hs-cTnT cut-off of 14 ng/L to previously proposed age-and gender-dependent hs-cTnT 99th percentile cut-offs (28 ng/L for >= 65 years, 9 ng/L for female and 15.5 ng/L for male patients). Patients were further clinically adjudicated into acute coronary syndrome (ACS) and non-ACS.Results: For patients >= 65 years, application of age-specified cut-offs resulted in a decrease of AMI from 29.8% to 18.3% in the entire cohort (n = 557) and 54.7% to 40.9% in the ACS subcohort (n = 225). Using gender-specific cut-offs, AMI-rate increased from 16.6% to 22.6% (entire cohort, n = 477) and 62.6% to 71.7% (ACS subcohort, n = 99) in women, whereas in men, rates decreased from 23.1% to 21.1% (entire cohort, n = 805) and 48.8% to 45.9% (ACS, n = 281), respectively. Age-specified cut-offs significantly reclassified patients for outcomes of 1-month and 3-month mortality in the entire and ACS cohort (14.2% net reclassification improvement, p < 0.001, respectively). Contrary, no significant differences in outcomes could be found using gender-specific cut-offs.Conclusions: While influence of gender-specific hs-cTnT cut-offs on diagnostic and prognostic reclassification was only modest in patients with suspected AMI, age-specific cut-offs showed a significant impact and may be considered for further validation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Age
- Gender
- AMI
- High-sensitivity cardiac Troponin T
- 99th percentile
- Diagnosis
- Prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Mueller-Hennesse ...
-
Lindahl, Bertil
-
Giannitsis, Evan ...
-
Biener, Moritz
-
Vafaie, Mehrshad
-
deFilippi, Chris ...
-
show more...
-
Christ, Michael
-
Santalo-Bel, Mig ...
-
Panteghini, Maur ...
-
Plebani, Mario
-
Verschuren, Fran ...
-
Jernberg, Tomas
-
French, John K.
-
Christenson, Rob ...
-
Body, Richard
-
McCord, James
-
Dilba, Peter
-
Katus, Hugo A.
-
Mueller, Christi ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
International Jo ...
- By the university
-
Uppsala University
-
Karolinska Institutet