Search: onr:"swepub:oai:DiVA.org:uu-293015" >
Safety and efficacy...
-
Velders, Matthijs A.Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
(author)
Safety and efficacy of ticagrelor and clopidogrel in primary percutaneous coronary intervention
- Article/chapterEnglish2016
Publisher, publication year, extent ...
-
2016-02-04
-
BMJ,2016
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-293015
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-293015URI
-
https://doi.org/10.1136/heartjnl-2015-308963DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Objective: The effects of ticagrelor in the subpopulation of patients with ST-elevation myocardial infarction (STEMI) were consistent with those observed in the overall Platelet Inhibition and Patient Outcomes (PLATO) study. However, this subgroup included patients initially or ultimately treated conservatively. The aim of this study is to compare treatment using ticagrelor with treatment using clopidogrel in patients with STEMI undergoing primary percutaneous coronary intervention (PCI).Methods: This post-hoc subgroup analysis compared ticagrelor with clopidogrel in 4949 PLATO patients with STEMI that were treated with primary PCI within 12h of admission. The primary endpoint was cardiovascular death, myocardial infarction or stroke. The safety endpoint consisted of any major bleeding. Secondary endpoints included stent thrombosis. The analysis was not adequately powered to establish significance of any treatment effects.Results: During a median of 286days, the primary endpoint occurred in 7.9% of ticagrelor-treated patients versus 8.6% of clopidogrel-treated patients (HR 0.91, 95% CI 0.75 to 1.12, p=0.38). Major bleeding occurred in 6.7% in ticagrelor-treated patients versus 6.8% of clopidogrel-treated patients (HR 0.97, 95% CI 0.77 to 1.22, p=0.79). No interactions were observed for the treatment effect of ticagrelor versus clopidogrel on the primary efficacy (p=0.40) and primary safety endpoints (p=0.15) as compared with the full PLATO population. Treatment with ticagrelor versus clopidogrel reduced the occurrence of definite stent thrombosis (HR 0.58, 95% CI 0.37 to 0.89, p=0.013).Conclusions: In the subset of patients with STEMI treated with primary PCI, ticagrelor compared with clopidogrel was safe, and efficacy outcomes were consistent with the overall PLATO trial.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Abtan, JeremieHop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, F-75877 Paris, France.
(author)
-
Angiolillo, Dominick J.Univ Florida, Coll Med Jacksonville, Dept Med, Jacksonville, FL USA.
(author)
-
Ardissino, DiegoUniv Parma, Azienda Osped, I-43100 Parma, Italy.
(author)
-
Harrington, Robert A.Stanford Univ, Dept Med, Stanford, CA 94305 USA.
(author)
-
Hellkamp, AnneDuke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.
(author)
-
Himmelmann, AndersAstraZeneca Res & Dev, Gothenburg, Sweden.
(author)
-
Husted, SteenHosp Unit West, Dept Med, Holstebro Herning Holste, Denmark.
(author)
-
Katus, Hugo A.Univ Klinikum Heidelberg, Med Klin, Heidelberg, Germany.
(author)
-
Meier, BernhardUniv Hosp Bern, CH-3010 Bern, Switzerland.
(author)
-
Schulte, Phillip J.Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.;Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
(author)
-
Storey, Robert F.Univ Sheffield, Dept Cardiovasc Sci, Sheffield, S Yorkshire, England.
(author)
-
Wallentin, LarsUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)larswall
(author)
-
Steg, Philippe GabrielHop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, F-75877 Paris, France.;INSERM, Unite 1148, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France.;Royal Brompton Hosp, ICMS, NHLI Imperial Coll, London SW3 6LY, England.
(author)
-
James, Stefan K.Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)stjam367
(author)
-
Uppsala universitetUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
Related titles
-
In:Heart: BMJ102:8, s. 617-6251355-60371468-201X
Internet link
Find in a library
-
Heart
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Velders, Matthij ...
-
Abtan, Jeremie
-
Angiolillo, Domi ...
-
Ardissino, Diego
-
Harrington, Robe ...
-
Hellkamp, Anne
-
show more...
-
Himmelmann, Ande ...
-
Husted, Steen
-
Katus, Hugo A.
-
Meier, Bernhard
-
Schulte, Phillip ...
-
Storey, Robert F ...
-
Wallentin, Lars
-
Steg, Philippe G ...
-
James, Stefan K.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Heart
- By the university
-
Uppsala University