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Synthesis of 11C-la...
Synthesis of 11C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [11C]CO
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- Stevens, Marc, 1984- (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Chow, Chow, 1986- (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Estrada, Sergio (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Eriksson, Jonas (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Asplund, Veronika (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Orlova, Anna (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Bogdan, Mitran (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Antoni, Gunnar (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Larhed, Mats (author)
- Uppsala universitet,Institutionen för läkemedelskemi,Science for Life Laboratory, SciLifeLab
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- Åberg, Ola, 1978- (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Odell, Luke (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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(creator_code:org_t)
- 2016-10-05
- 2016
- English.
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In: ChemistryOpen. - : John Wiley & Sons. - 2191-1363. ; 5:6, s. 566-573
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Abstract
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- Herein we describe the development of new methodologyfocusing on 11C-labelling of sulfonyl carbamates in a multicomponentreaction comprising a sulfonyl azide, an alkyl alcohol and [11C]CO. Anumber of 11C-labelled sulfonyl carbamates were synthesised andisolated, and the developed methodology was then applied in thepreparation of a biologically active molecule. The target compoundwas obtained in 18±8% isolated radiochemical yield and wasevaluated for binding properties in a tumor cell assay, as well asundergoing in vivo biodistribution and imaging studies. Thisrepresents the first successful radiolabelling of C21, a non-peptideangiotensin II receptor subtype 2 agonist currently in clinical trials.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stevens, Marc, 1 ...
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Chow, Chow, 1986 ...
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Estrada, Sergio
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Eriksson, Jonas
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Asplund, Veronik ...
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Orlova, Anna
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show more...
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Bogdan, Mitran
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Antoni, Gunnar
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Larhed, Mats
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Åberg, Ola, 1978 ...
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Odell, Luke
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
- Articles in the publication
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ChemistryOpen
- By the university
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Uppsala University