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  • Nordeman, PatrikUppsala universitet,Avdelningen för Molekylär Avbildning,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden (author)

C-11 and F-18 Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-02-25
  • American Chemical Society (ACS),2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-296858
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-296858URI
  • https://doi.org/10.1021/acsmedchemlett.5b00309DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122273URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:  Swedish Research Council; Swedish Foundation for Strategic Research; LiU-Neuro; Ehrling-Persson Foundation; Goran-Gustafsson Foundation; ERC Starting Independent Researcher grant (Project: MUMID)Vid tiden för disputation förelåg publikationen som manuskript
  • Three oligothiophenes were evaluated as PET ligands for the study of local and systemic amyloidosis ex vivo using tissue from patients with amyloid deposits and in vivo using healthy animals and PET-CT. The ex vivo binding studies revealed that all three labeled compounds bound specifically to human amyloid deposits. Specific binding was found in the heart, kidney, liver, and spleen. To verify the specificity of the oligothiophenes toward amyloid deposits, tissue sections with amyloid pathology were stained using the fluorescence exhibited by the compounds and evaluated with multiphoton microscopy. Furthermore, a in vivo monkey PET-CT study showed very low uptake in the brain, pancreas, and heart of the healthy animal indicating low nonspecific binding to healthy tissue. The biological evaluations indicated that this is a promising group of compounds for the visualization of systemic and localized amyloidosis.

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  • Johansson, Leif B. G.Linköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)leijo35 (author)
  • Bäck, MarcusLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)marba90 (author)
  • Estrada, SergioUppsala universitet,Plattformen för Preklinisk PET-MRI,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.(Swepub:uu)seest517 (author)
  • Hall, HåkanUppsala universitet,Plattformen för Preklinisk PET-MRI,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden. (author)
  • Sjölander, DanielLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)dansj00 (author)
  • Westermark, Gunilla T.Uppsala universitet,Institutionen för medicinsk cellbiologi,Department of Medicinal Cell Biology, Uppsala University, Uppsala, Sweden(Swepub:uu)gunwe105 (author)
  • Westermark, PerUppsala universitet,Klinisk och experimentell patologi,Per Westermark,Department of Immunology, Genetics and Pathology, Uppsala University, UppsalaSweden(Swepub:uu)perweste (author)
  • Nilsson, LarsUniv Oslo, Dept Pharmacol, N-0316 Oslo, Norway.,Department of Pharmacology, University of Oslo, Oslo, Norway (author)
  • Hammarström, PerLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)perha81 (author)
  • Nilsson, K. Peter R.Linköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)petni61 (author)
  • Antoni, GunnarUppsala universitet,Avdelningen för Molekylär Avbildning,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden(Swepub:uu)gunnarat (author)
  • Uppsala universitetAvdelningen för Molekylär Avbildning (creator_code:org_t)

Related titles

  • In:ACS Medicinal Chemistry Letters: American Chemical Society (ACS)7:4, s. 368-3731948-5875

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