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Two are Better than...
Two are Better than One : Combining ZnO and MgF2 Nanoparticles Reduces Streptococcus pneumoniae and Staphylococcus aureus Biofilm Formation on Cochlear Implants
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- Natan, Michal (author)
- Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel.;Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel.
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- Edin, Fredrik (author)
- Uppsala universitet,Klinisk immunologi,Öron-, näs- och halssjukdomar
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- Perkas, Nina (author)
- Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel.
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- Yacobi, Gila (author)
- Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel.;Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel.
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- Perelshtein, Ilana (author)
- Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel.
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- Segal, Elad (author)
- Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel.
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- Homsy, Alexandra (author)
- Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, HES SO, Eplatures Grise 17, CH-2300 La Chaux De Fonds, Switzerland.
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- Laux, Edith (author)
- Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, HES SO, Eplatures Grise 17, CH-2300 La Chaux De Fonds, Switzerland.
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- Keppner, Herbert (author)
- Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, HES SO, Eplatures Grise 17, CH-2300 La Chaux De Fonds, Switzerland.
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- Rask-Andersen, Helge (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Gedanken, Aharon (author)
- Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel.
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- Banin, Ehud (author)
- Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel.;Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel.
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Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel;Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel. Klinisk immunologi (creator_code:org_t)
- 2016-03-03
- 2016
- English.
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In: Advanced Functional Materials. - : Wiley. - 1616-301X .- 1616-3028. ; 26:15, s. 2473-2481
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Streptococcus pneumoniae (S. pneumoniae) and Staphylococcus aureus (S.aureus) are considered the most common colonizers of cochlear implants (CI), which have prompted the search for new ways to inhibit their growth and biofilm development. In the current study, CI-based platforms are prepared and sonochemically coated with ZnO or MgF2 nanoparticles (NPs), two agents previously shown to possess antibacterial properties. Additionally, a method is developed for coating both ZnO and MgF2 on the same platform to achieve synergistic activity against both pathogens. Each surface is characterized, and the optimal conditions for the NP homogenous distribution on the surface are determined. The ZnO-MgF2 surface significantly reduces the S. pneumoniae and S. aureus biofilm compared with the surfaces coated with either ZnO or MgF2, even though it contains smaller amounts of each NP type. Importantly, leaching assays show that the NPs remain anchored to the surface for at least 7 d. Finally, biocompatibility studies demonstrate that coating with low concentrations of ZnO-MgF2 results in no toxicity toward primary human fibroblasts from the auditory canal. Taken together, these findings underscore the potential of using NP combinations such as the one presented here to efficiently inhibit bacterial colonization and growth on medical devices such as CIs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- antibiofilm
- bacteria
- cochlear
- implants
- nanoparticles
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Natan, Michal
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Edin, Fredrik
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Perkas, Nina
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Yacobi, Gila
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Perelshtein, Ila ...
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Segal, Elad
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Homsy, Alexandra
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Laux, Edith
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Keppner, Herbert
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Rask-Andersen, H ...
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Gedanken, Aharon
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Banin, Ehud
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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Uppsala University