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Pancreatic perfusio...
Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes
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- Carlbom, Lina (författare)
- Uppsala universitet,Radiologi
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- Espes, Daniel (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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- Eriksson, Olof (författare)
- Uppsala universitet,Avdelningen för Molekylär Avbildning
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- Johansson, Lars (författare)
- Uppsala universitet,Radiologi
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- Jansson, Leif (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Korsgren, Olle (författare)
- Uppsala universitet,Klinisk immunologi
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- Ahlström, Håkan (författare)
- Uppsala universitet,Radiologi
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
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(creator_code:org_t)
- 2016-06-16
- 2016
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 59:9, s. 1968-1972
- Relaterad länk:
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- AIMS/HYPOTHESIS: The aim of this study was to investigate pancreatic perfusion and its response to a glucose load in patients with type 1 diabetes mellitus compared with non-diabetic ('healthy') individuals.METHODS: Eight individuals with longstanding type 1 diabetes and ten sex-, age- and BMI-matched healthy controls underwent dynamic positron emission tomography scanning with (15)O-labelled water before and after intravenous administration of glucose. Perfusion in the pancreas was measured. Portal and arterial hepatic perfusion were recorded as references.RESULTS: Under fasting conditions, total pancreatic perfusion was on average 23% lower in the individuals with diabetes compared with healthy individuals. Glucose increased total pancreatic and portal hepatic blood perfusion in healthy individuals by 48% and 38%, respectively. In individuals with diabetes there was no significant increase in either total pancreatic or portal hepatic perfusion.CONCLUSIONS/INTERPRETATION: Individuals with type 1 diabetes have reduced basal pancreatic perfusion and a severely impaired pancreatic and splanchnic perfusion response to intravenous glucose stimulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Blood flow; Glucose; Pancreas; Pancreatic islets; Perfusion; Type 1 diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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