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  • Verhoef, T. I.UCL, Dept Appl Hlth Res, London, England; Univ Utrecht, Div Pharmacoepidemiol & Clin Pharmacol, Dept Pharmaceut Sci, Utrecht, Netherlands (author)

Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-06-07
  • Springer Science and Business Media LLC,2016
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-297969
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297969URI
  • https://doi.org/10.1038/tpj.2016.41DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134296824URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We aimed to assess the cost-effectiveness of pharmacogenetic-guided dosing of warfarin in patients with atrial fibrillation (AF) in the United Kingdom and Sweden. Data from EU-PACT, a randomized controlled trial in newly diagnosed AF patients, were used to model the incremental costs per quality-adjusted life-year (QALY) gained by pharmacogenetic-guided warfarin dosing versus standard treatment over a lifetime horizon. Incremental lifetime costs were £26 and 382 Swedish kronor (SEK) and incremental QALYs were 0.0039 and 0.0015 in the United Kingdom and Sweden, respectively. The corresponding incremental cost-effectiveness ratios (ICERs) were £6 702 and 253 848 SEK per QALY gained. The ICER was below the willingness-to-pay threshold of £20 000 per QALY gained in 93% of the simulations in the United Kingdom and below 500 000 SEK in 67% of the simulations in Sweden. Our data suggest that pharmacogenetic-guided dosing of warfarin is a cost-effective strategy to improve outcomes of patients with AF treated with warfarin in the United Kingdom and in Sweden.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Redekop, W. K.Erasmus Univ, Inst Med Technol Assessment, Rotterdam, Netherlands (author)
  • Langenskiöld, SophieUppsala universitet,Hälsoekonomi,Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden(Swepub:uu)sopla565 (author)
  • Kamali, F.Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England (author)
  • Wadelius, MiaUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)miawadel (author)
  • Burnside, G.Univ Liverpool, Inst Translat Med, Block A,Waterhouse Bldg,1-5 Brownlow St, Liverpool L69 3GL, Merseyside, England (author)
  • Maitland-van der Zee, A-H.Univ Utrecht, Div Pharmacoepidemiol & Clin Pharmacol, Dept Pharmaceut Sci, Utrecht, Netherlands (author)
  • Hughes, D. A.Bangor Univ, Ctr Hlth Econ & Med Evaluat, Bangor, North Wales, Wales (author)
  • Pirmohamed, M.Univ Liverpool, Inst Translat Med, Block A,Waterhouse Bldg,1-5 Brownlow St, Liverpool L69 3GL, Merseyside, England (author)
  • UCL, Dept Appl Hlth Res, London, England; Univ Utrecht, Div Pharmacoepidemiol & Clin Pharmacol, Dept Pharmaceut Sci, Utrecht, NetherlandsErasmus Univ, Inst Med Technol Assessment, Rotterdam, Netherlands (creator_code:org_t)

Related titles

  • In:The Pharmacogenomics Journal: Springer Science and Business Media LLC16:5, s. 478-4841470-269X1473-1150

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