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Performance of plas...
Performance of plasma calprotectin as a biomarker of early sepsis : a pilot study
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- Simm, Mikael (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Söderberg, Ewa (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Castegren, Markus (author)
- Karolinska Institutet
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- Nilsen, Tom (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Eriksson, Mats (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Lipcsey, Miklós (author)
- Uppsala universitet,Hedenstiernalaboratoriet,Anestesiologi och intensivvård
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(creator_code:org_t)
- Future Medicine Ltd, 2016
- 2016
- English.
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In: Biomarkers in Medicine. - : Future Medicine Ltd. - 1752-0363 .- 1752-0371. ; 10:8, s. 811-818
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- AIM: To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission.MATERIALS & METHODS: Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without inflammation (n = 7) groups.RESULTS: Calprotectin was 4.3 (2.6-8.2; mg/l; median [interquartile range]) in the sepsis, 2.8 (1.6-4.4) in the postoperative and 0.7 (0.4-1.6) in the intoxication groups. Area under the receiver operating characteristic curve for sepsis versus intoxication group was: 0.95, for sepsis versus postoperative groups: 0.65 and for survivors versus nonsurvivors: 0.70.CONCLUSION: Calprotectin was a sensitive marker of systemic inflammation, is a potential sepsis marker and performed well as mortality predictor in this pilot study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- calprotectin; sepsis; systemic inflammatory response syndrome
Publication and Content Type
- ref (subject category)
- art (subject category)
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