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Collagen epitope ex...
Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis
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- Andersson, Sofia E M, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Eneljung, Tove, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Tengvall, Sara, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Jirholt, Pernilla, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Stern, Anna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Henningsson, Louise, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Liang, Bibo (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Med Inflammat Res, Solna, Sweden.;Southern Med Univ, Guangzhou, Guangdong, Peoples R China.
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- Thorarinsdottir, Katrin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Kihlberg, Jan (author)
- Uppsala universitet,Organisk kemi
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- Holmdahl, Rikard (author)
- Karolinska Institutet
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- Mårtensson, Inga-Lill, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Gustafsson, Kenth (author)
- UCL, Inst Child Hlth, Mol Immunol Unit, London, England.
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- Gjertsson, Inger, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- 2016-06-14
- 2016
- English.
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In: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6362. ; 18
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https://arthritis-re...
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Abstract
Subject headings
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- Background: The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. Methods: To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. Results: Presentation of the CII-peptide on B cells significantly reduced the frequency and severity of arthritis as well as the serum levels of CII -specific IgG antibodies. Further, both frequency and suppressive function of regulatory T cells were increased in tolerized mice. Adoptive transfer of regulatory T cells from tolerized mice to naive mice ameliorated the development of CII-induced arthritis. Conclusion: Our data suggest that endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Tolerance
- B cells
- B lymphocytes
- Arthritis
- Collagen
- Collagen type II
- Gene therapy
- Antigen presentation
- Antigen presentation; Arthritis; B cells; B lymphocytes; Collagen; Collagen type II; Gene therapy; Tolerance
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andersson, Sofia ...
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Eneljung, Tove, ...
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Tengvall, Sara, ...
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Jirholt, Pernill ...
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Stern, Anna
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Henningsson, Lou ...
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show more...
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Liang, Bibo
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Thorarinsdottir, ...
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Kihlberg, Jan
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Holmdahl, Rikard
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Mårtensson, Inga ...
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Gustafsson, Kent ...
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Gjertsson, Inger ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Arthritis Resear ...
- By the university
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Uppsala University
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University of Gothenburg
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Karolinska Institutet