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Branched-chain amin...
Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young
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- Mangge, Harald (author)
- Med Univ Graz, Clin Inst Med, Auenbruggerpl 15, A-8036 Graz, Austria.;Med Univ Graz, Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
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- Zelzer, Sieglinde (author)
- Med Univ Graz, Clin Inst Med, Auenbruggerpl 15, A-8036 Graz, Austria.;Med Univ Graz, Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
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- Prueller, Florian (author)
- Med Univ Graz, Clin Inst Med, Auenbruggerpl 15, A-8036 Graz, Austria.;Med Univ Graz, Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
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- Schnedl, Wolfgang J. (author)
- General Practice Internal Med, Bruck An Der Mur, Austria.
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- Weghuber, Daniel (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
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- Enko, Dietmar (author)
- Gen Hosp Steyr, Inst Lab Med, Steyr, Austria.
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- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Haybaeck, Johannes (author)
- Med Univ Graz, Dept Pathol, Graz, Austria.
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- Meinitzer, Andreas (author)
- Med Univ Graz, Clin Inst Med, Auenbruggerpl 15, A-8036 Graz, Austria.;Med Univ Graz, Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
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Med Univ Graz, Clin Inst Med, Auenbruggerpl 15, A-8036 Graz, Austria;Med Univ Graz, Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria. General Practice Internal Med, Bruck An Der Mur, Austria. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Journal of Nutritional Biochemistry. - : Elsevier BV. - 0955-2863 .- 1873-4847. ; 32, s. 123-127
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cardiovascular risk is increased in obese subjects. Nevertheless, some overweight and obese remain cardiometabolically healthy (CMH), and normal-weight persons develop cardiovascular disease (CVD). Herein, we investigate the potential of branched-chain amino acids (BCAAs) to identify an increased CVD risk in a cross-sectional study of 666 adults and juveniles (age 25.3 +/- 12.8 years), classified as lean, overweight or obese. Cardiometabolic groups were defined by cutoffs of systolic blood pressure <130 mmHg, diastolic blood pressure<85 mmHg, glucose <125 mg/dl, triglycerides <150 mg/dl, HDL-cholesterol>40 mg/dl (males), HDL-cholesterol>50 mg/dl (females) and HOMA-IR<5. CMH had <= 1 cutoff, and cardiometabolically abnormal (CMA) had >= 2 cutoffs. Amino acids were measured by high-pressure lipid chromatography after precipitation of serum with perchloric acid and derivatization with o-phthalaldehyde. Valine correlated with 5, leucine correlated with 3 and isoleucine correlated with 5 of the cardiac risk classification factors. Valine and leucine were significantly higher in the obese (P<.001, P=.015, respectively), overweight (P<.001, P=.015, respectively) and lean (P=.024, P=.012, respectively) CMA compared to CMH subjects. Isoleucine showed except of the lean group the same results. Taken together, BCAAs, especially valine and leucine, are proposed as a cardiometabolic risk marker independent of body mass index (BMI) category.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Branched-chain amino acids
- Cardiometabolic risk
- Body mass index
Publication and Content Type
- ref (subject category)
- art (subject category)
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