Search: onr:"swepub:oai:DiVA.org:uu-299719" >
Genetic basis of PD...
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Georgiou, KonstantinosKarolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.
(author)
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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American Society of Hematology,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-299719
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299719URI
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https://doi.org/10.1182/blood-2015-12-686550DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133775050URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBCL. PIM1 and TP63 were also identified as novel translocation partners for PD-L1/PD-L2. Fluorescence in situ hybridization was furthermore used to rapidly screen an expanded DLBCL cohort. Collectively, a subset of samples was found to be affected by gains (12%), amplifications (3%), and translocations (4%) of the PD-L1/PD-L2 locus. RNA sequencing data coupled with immunohistochemistry revealed that these cytogenetic alterations correlated with increased expression of PD-L1 but not of PD-L2. Moreover, cytogenetic alterations affecting the PD-L1/PD-L2 locus were more frequently observed in the non-germinal center B cell-like (non-GCB) subtype of DLBCL. These findings demonstrate the genetic basis of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1-PD-L1/PD-L2 axis might benefit DLBCL patients, especially those belonging to the more aggressive non-GCB subtype.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Chen, LongyunKarolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China.
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Berglund, MattiasKarolinska Institutet
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Ren, WeichengKarolinska Institutet
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de Miranda, Noel F. C. C.Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands.
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Lisboa, SusanaUniv Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
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Fangazio, MarcoColumbia Univ, Inst Canc Genet, New York, NY USA.
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Zhu, ShidaBGI Shenzhen, Shenzhen, Peoples R China.
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Hou, YongBGI Shenzhen, Shenzhen, Peoples R China.
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Wu, KuiBGI Shenzhen, Shenzhen, Peoples R China.
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Fang, WenfengSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
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Wang, XianhuoTianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
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Meng, BinTianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
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Zhang, LiSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
(author)
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Zeng, YixinSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
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Bhagat, GovindColumbia Univ, Dept Pathol & Cell Biol, New York, NY USA.
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Nordenskjold, MagnusKarolinska Institutet
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Sundström, ChristerUppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini(Swepub:uu)chrisund
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Enblad, GunillaUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)gunienbl
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Dalla-Favera, RiccardoColumbia Univ, Inst Canc Genet, New York, NY USA.
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Zhang, HuilaiTianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
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Teixeira, Manuel R.Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
(author)
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Pasqualucci, LauraColumbia Univ, Inst Canc Genet, New York, NY USA.
(author)
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Peng, RoujunSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
(author)
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Pan-Hammarstrom, QiangKarolinska Institutet
(author)
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Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China.
(creator_code:org_t)
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In:Blood: American Society of Hematology127:24, s. 3026-30340006-49711528-0020
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Georgiou, Konsta ...
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Chen, Longyun
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Ren, Weicheng
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Lisboa, Susana
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Fangazio, Marco
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Zhu, Shida
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Hou, Yong
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Wang, Xianhuo
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Meng, Bin
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Zhang, Li
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Zeng, Yixin
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Sundström, Chris ...
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Enblad, Gunilla
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Dalla-Favera, Ri ...
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