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Heparanase expressi...
Heparanase expression upregulates platelet adhesion activity and thrombogenicity
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- Cui, Hao (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Tan, Ying-xia (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Beijing Inst Transfus Med, Dept Tissue Engn, Beijing, Peoples R China.
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- Österholm, Cecilia (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Nova SE Univ, Cell Therapy Inst, Ft Lauderdale, FL 33314 USA.
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- Zhang, Xiao-Qun (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Hedin, Ulf (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Vlodavsky, Israel (author)
- Technion Israel Inst Technol, Fac Med, Canc & Vasc Biol Res Ctr Rappaport, Haifa, Israel.
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- Li, Jin-Ping (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- 2016-04-23
- 2016
- English.
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:26, s. 39486-39496
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Heparanase is an endo-glucuronidase that specifically cleaves heparan sulfate (HS) and heparin polysaccharides. The enzyme is expressed at low levels in normal tissues, but is often upregulated under pathological conditions such as cancer and inflammation. Normal human platelets express exceptionally high levels of heparanase, but the functional consequences of this feature remain unknown. We investigated functional roles of heparanase by comparing the properties of platelets expressing high (Hpa-tg) or low (Ctr) levels of heparanase. Upon activation, Hpa-tg platelets exhibited a much stronger adhesion activity as compared to Ctr platelets, likely contributing to a higher thrombotic activity in a carotid thrombosis model. Furthermore, we found concomitant upregulated expression of both heparanase and CD62P (P-selectin) upon activation of mouse and human platelets. As platelets play important roles in tumor metastasis, these findings indicate contribution of the platelet heparanase to hyper-thrombotic conditions often seen in patients with metastatic cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- heparanase
- heparan sulfate
- platelet
- platelet adhesion
- thrombosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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