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Percutaneous left atrial appendage occlusion : the Munich consensus document on definitions, endpoints and data collection requirements for clinical studies

Tzikas, Apostolos (author)
AHEPA Univ Hosp, Thessaloniki, Greece.
Holmes, David R., Jr. (author)
Mayo Clin, Rochester, MN USA.
Gafoor, Sameer (author)
CardioVasc Ctr Frankfitrt, Frankfurt, Germany.
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Ruiz, Carlos E. (author)
Hackensack UMC Heart & Vasc Hosp, Hackensack, NJ USA.;Joseph M Sanzari Childrens Hosp, Hackensack, NJ USA.
Blomström-Lundqvist, Carina (author)
Uppsala universitet,Kardiologi-arrytmi
Diener, Hans-Christoph (author)
Univ Duisburg Essen, Univ Hosp Essen, Dept Neurol, Essen, Germany.
Cappato, Riccardo (author)
IRCCS Humanitas Res Hosp, Arrhythmia & Electrophysiol Res Ctr, Milan, Italy.;Humanitas Gavazzeni, Arrhythmia & Electrophysiol Ctr 2, Bergamo, Italy.
Kar, Saibal (author)
Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
Lee, Randal J. (author)
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
Byrne, Robert A. (author)
Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
Ibrahim, Reda (author)
Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada.
Lakkireddy, Dhanunjaya (author)
Univ Kansas Hosp, KU Cardiovasc Res Inst, Bloch Heart Rhythm Ctr, Kansas City, KS USA.
Soliman, Osama I. (author)
Erasmus MC, Thoraxctr, Cardialysis, Rotterdam, Netherlands.;Erasmus MC, Thoraxctr, Dept Cardiol, Rotterdam, Netherlands.
Naebauer, Michael (author)
Univ Munich, Med Klin & Poliklin 1, Munich, Germany.
Schneider, Steffen (author)
Fdn IHF, Stung Inst Herzinfarktforsch, Ludwigshafen, Germany.
Brachman, Johannes (author)
Coburg GmbH, Med Hosp Klinikum 2, Coburg, Germany.
Saver, Jeffrey L. (author)
Univ Calif Los Angeles, David Geffen Sch Med, Comprehens Stroke Ctr, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA.
Tiemane, Klaus (author)
Tech Univ Munich, Dept Nucl Med, Munich, Germany.
Sievert, Horst (author)
CardioVasc Ctr Frankfitrt, Frankfurt, Germany.
Camm, A. John (author)
St Georges Univ London, Cardiovasc, London, England.;St Georges Univ London, Cell Sci Res Inst, London, England.
Lewalter, Thorsten (author)
Univ Munich, Med Klin & Poliklin 1, Munich, Germany.;Clin Munich Thalkirchen, Peter Osypka Heart Ctr, Dept Med Cardiol & Intens Care, Munich, Germany.
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AHEPA Univ Hosp, Thessaloniki, Greece Mayo Clin, Rochester, MN USA. (creator_code:org_t)
2016
2016
English.
In: EuroIntervention. - 1774-024X .- 1969-6213. ; 12:1, s. 103-111
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The increasing interest in left atrial appendage occlusion (LAAO) for ischaemic stroke prevention in atrial fibrillation (AF) fuels the need for more clinical data on the safety and effectiveness of this therapy. Besides an assessment of the effectiveness of the therapy in specific patient groups, comparisons with pharmacological stroke prophylaxis, surgical approaches and other device-based therapies are warranted. This paper documents the consensus reached among clinical experts in relevant disciplines from Europe and North America, European cardiology professional societies and representatives from the medical device industry regarding defmitions for parameters and endpoints to be assessed in clinical studies. Adherence to these definitions is proposed in order to achieve a consistent approach across clinical studies on LAAO among the involved stakeholders and various clinical disciplines and thereby facilitate continued evaluation of therapeutic strategies available.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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ref (subject category)
art (subject category)

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