onr:"swepub:oai:DiVA.org:uu-300102"
Search: onr:"swepub:oai:DiVA.org:uu-300102" > Investigating the a...
- 1 of 1
- Previous record
- Next record
- To hitlist
Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival
-
- Wulaningsih, Wahyu (author)
- Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.;Gadjah Mada Univ, Fac Med, Div Hematol Oncol, Yogyakarta, Indonesia.
-
- Holmberg, Lars (author)
- Uppsala universitet,Endokrinkirurgi,Uppsala kliniska forskningscentrum (UCR),Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.
-
- Garmo, Hans (author)
- Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.;Reg Canc Ctr, Uppsala, Sweden.
- show more...
- show less...
- Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England;Gadjah Mada Univ, Fac Med, Div Hematol Oncol, Yogyakarta, Indonesia. Endokrinkirurgi (creator_code:org_t)
- 2016
- 2016
- English.
- In: Oncoimmunology. - 2162-4011 .- 2162-402X. ; 5:6
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE >= 35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan-Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70-0.99. A similar trend was seen with specific IgE scores overall (P-trend = 0.007) and in women (P-trend = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (T(H)2)-biased response in development of some cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Allergy
- atopy
- cancer
- immunoglobulin E
- cohort
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Oncoimmunology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Wulaningsih, Wah ...
- Holmberg, Lars
- Garmo, Hans
- Karagiannis, Sop ...
- Ahlstedt, Staffa ...
- Malmstrom, Hakan
- show more...
- Lambe, Mats
- Hammar, Niklas
- Walldius, Goran
- Jungner, Ingmar
- Ng, Tony
- Van Hemelrijck, ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Oncoimmunology
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
