In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use

Eriksson, OlofUppsala universitet,Avdelningen för Molekylär Avbildning,Univ Turku, Turku PET Ctr, Turku, Finland.;Abo Akad Univ, Dept Biosci, Turku, Finland. (author)

In vivo imaging of beta cells with radiotracers : state of the art, prospects and recommendations for development and use

Radiotracer imaging is characterised by high in vivo sensitivity, with a detection limit in the lower picomolar range. Therefore, radiotracers represent a valuable tool for imaging pancreatic beta cells. High demands are made of radiotracers for in vivo imaging of beta cells. Beta cells represent only a small fraction of the volume of the pancreas (usually 1-3%) and are scattered in the tiny islets of Langerhans throughout the organ. In order to be able to measure a beta cell-specific signal, one has to rely on highly specific tracer molecules because current in vivo imaging technologies do not allow the resolution of single islets in humans non-invasively. Currently, a considerable amount of preclinical data are available for several radiotracers and three are under clinical evaluation. We summarise the current status of the evaluation of these tracer molecules and put forward recommendations for their further evaluation.

Laughlin, MarenNIDDK, NIH, Bethesda, MD 20892 USA. (author)
Brom, MaartenRadboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands. (author)
Nuutila, PirjoUniv Turku, Turku PET Ctr, Turku, Finland. (author)
Roden, MichaelUniv Dusseldorf, Fac Med, Dept Endocrinol & Diabetol, Dusseldorf, Germany.;Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany. (author)
Hwa, AlbertJDRF, Discovery Res, New York, NY USA. (author)
Bonadonna, RiccardoUniv Parma, Dept Clin & Expt Med, Div Endocrinol, I-43100 Parma, Italy.;AOU Parma, Parma, Italy. (author)
Gotthardt, MartinRadboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands. (author)
Uppsala universitetAvdelningen för Molekylär Avbildning (creator_code:org_t)

In:Diabetologia: Springer Science and Business Media LLC59:7, s. 1340-13490012-186X1432-0428

By the author/editor: Eriksson, Olof; Laughlin, Maren; Brom, Maarten; Nuutila, Pirjo; Roden, Michael; Hwa, Albert; show more...; Bonadonna, Ricca ...; Gotthardt, Marti ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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