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Increased prevalenc...
Increased prevalence of prior malignancies and autoimmune diseases in patients diagnosed with chronic myeloid leukemia
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- Gunnarsson, Niklas (author)
- Umeå universitet,Medicin,Sundsvall Research Unit, Umeå University,Umeå University, Sweden
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden
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- Stenke, L. (author)
- Karolinska Institutet
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- Wållberg-Jonsson, Solveig (author)
- Umeå universitet,Reumatologi,Umeå University, Sweden
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- Sandin, F. (author)
- Reg Canc Ctr, Uppsala, Sweden.,Regional Cancer Centre, Sweden
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- Björkholm, M. (author)
- Karolinska Institutet
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- Dreimane, Arta (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Lambe, M. (author)
- Karolinska Institutet
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- Markevarn, B. (author)
- Univ Umea Hosp, Dept Hematol, Umea, Sweden.
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- Olsson-Strömberg, Ulla (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden
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- Wadenvik, H. (author)
- Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.,Sahlgrens University Hospital, Sweden
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- Richter, J. (author)
- Skane Univ Hosp, Dept Hematol & Vasc Disorders, Lund, Sweden.,Skåne University Hospital, Sweden
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- Själander, Anders (author)
- Umeå universitet,Medicin,Sundsvall Research Unit, Umeå University,Umeå University, Sweden
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(creator_code:org_t)
- 2016-03-08
- 2016
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 30:7, s. 1562-1567
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Abstract
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- We recently reported an increased incidence of second malignancies in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKI). To elucidate whether this increase may be linked, not to TKI but rather to a hereditary or acquired susceptibility to develop cancer, we estimated the prevalence of malignancies, autoimmune disease (AD) and chronic inflammatory disease (CID) in CML patients prior to their CML diagnosis. Nationwide population-based registers were used to identify patients diagnosed with CML in Sweden 2002-2012 and to estimate the prevalence of other malignancies, AD and CID prior to their CML diagnosis. For each patient with CML, five matched controls were selected from the general population. Conditional logistic regression was used to calculate odds ratios (OR). Nine hundred and eighty-four CML patients were assessed, representing more than 45 000 person-years of follow-up. Compared with matched controls, the prevalence of prior malignancies and AD was elevated in CML patients: OR 1.47 (95% confidence interval (CI) 1.20-1.82) and 1.55 (95% CI 1.21-1.98), respectively. No associations were detected between CML and previous CID. An increased prevalence of other malignancies and AD prior to the diagnosis of CML suggest that a hereditary or acquired predisposition to cancer and/or autoimmunity is involved in the pathogenesis of CML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- ref (subject category)
- art (subject category)
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Leukemia
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- By the author/editor
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Gunnarsson, Nikl ...
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Höglund, Martin
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Stenke, L.
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Wållberg-Jonsson ...
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Sandin, F.
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Björkholm, M.
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show more...
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Dreimane, Arta
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Lambe, M.
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Markevarn, B.
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Olsson-Strömberg ...
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Wadenvik, H.
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Richter, J.
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Själander, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Leukemia
- By the university
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Uppsala University
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Umeå University
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Linköping University
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Karolinska Institutet