Malignancies in Swedish persons with haemophilia: a longitudinal registry study

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Lövdahl, SusannaLund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Skåne University Hospital (author)

Malignancies in Swedish persons with haemophilia : a longitudinal registry study

Article/chapterEnglish2016

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2016
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LIBRIS-ID:oai:DiVA.org:uu-303021
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303021URI
https://doi.org/10.1097/MBC.0000000000000339DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134010408URI
https://lup.lub.lu.se/record/31a83e10-76bb-4962-8b4a-6b54f4fcad12URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype

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The aim of the study was to investigate, over time, the incidence of and mortality due to malignant diseases among persons with haemophilia, compared to matched controls. Persons with haemophilia A or B were enrolled via registries at each haemophilia centre, as well as from the National Patient Registry, and were compared to five sex and age-matched controls per patient. Data from the national Cancer Registry were linked to the study participants. A total of 1431 persons with haemophilia and 7150 matched controls were enrolled. Between the years 1972 and 2008, 164 malignancies were reported. The most common type of cancer among patients was prostate cancer, followed by haematologic malignancies, including lymphoma and leukaemia, which were significantly more frequent in patients [ n=35 (2.4%) vs. n=60 (0.8%); P < 0.001]. Malignancies in bladder and other urinary organs were also significantly different [ n=21 (1.5%) vs. n=46 (0.6%); P < 0.01]. The overall incidence rate ratio of malignancies per 1000 person-years compared to the controls was 1.3 [95% confidence interval (CI) 1.1, 1.6]. In subgroup analysis, the corresponding incidence rate ratios per 1000 person-years for persons with severe haemophilia was 1.7 (95% CI 0.9, 3.1) and that for mild/moderate haemophilia 1.1 (95% CI 0.8, 1.5). Swedish persons with haemophilia had a significantly higher incidence of malignant diseases than controls. These were primarily haematologic malignancies and cancer in urinary organs, and the difference independent of any co-infections with HIV and/or viral hepatitis. The findings indicate the importance of further studies and close follow-up of malignancies in persons with haemophilia.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
cancer
haemophilia
hepatitis
HIV
malignancies

Added entries (persons, corporate bodies, meetings, titles ...)

Henriksson, Karin M.Uppsala universitet,Kardiovaskulär epidemiologi,AstraZeneca, Dept Epidemiol, R&D, Molndal, Sweden.,Uppsala University Hospital(Swepub:uu)karhe322 (author)
Baghaei, FaribaSahlgrens Univ Hosp, Dept Med Hematol & Coagulat Disorders, Coagulat Ctr, Gothenburg, Sweden.,AstraZeneca, Sweden (author)
Holmström, MargaretaKarolinska Institutet (author)
Berntorp, ErikLund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups(Swepub:lu)medf-ebe (author)
Astermark, JanLund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups(Swepub:lu)medf-jas (author)
Klinisk koagulationsmedicin, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Blood Coagulation and Fibrinolysis27:6, s. 631-6360957-52351473-5733

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By the author/editor: Lövdahl, Susanna; Henriksson, Kari ...; Baghaei, Fariba; Holmström, Marga ...; Berntorp, Erik; Astermark, Jan

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