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  • Cooper, Ian R.Redx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-303258
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303258URI
  • https://doi.org/10.1016/j.bmcl.2016.07.061DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • There is an urgent and unmet medical need for new antibacterial drugs that tackle infections caused by multidrug-resistant (MDR) pathogens. During the course of our wider efforts to discover and exploit novel mechanism of action antibacterials, we have identified a novel series of isothiazolone based inhibitors of bacterial type II topoisomerase. Compounds from the class displayed excellent activity against both Gram-positive and Gram-negative bacteria with encouraging activity against a panel of MDR clinical Escherichia coli isolates when compared to ciprofloxacin. Representative compounds also displayed a promising in vitro safety profile.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • McCarroll, Andrew J.Redx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • McGarry, DavidRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Kirkham, JamesRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Pichowicz, MarkRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Walker, RolfRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Warrilow, CatherineRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Salisbury, Anne-MarieRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Savage, Victoria J.Redx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Moyo, EmmanuelRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Forward, HenryRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Cheung, JonathanRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Metzger, RichardRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Gault, ZoeRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Nelson, GaryRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Hughes, DiarmaidUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)diarhugh (author)
  • Cao, ShaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)shaca305 (author)
  • Maclean, JohnRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Charrier, CedricRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Craighead, MarkRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Best, StuartRedx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Stokes, Neil R.Redx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Ratcliffe, Andrew J.Redx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. (author)
  • Redx Pharma, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England.Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

Related titles

  • In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV26:17, s. 4179-41830960-894X1464-3405

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