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Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET
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- Harms, Hendrik Johannes (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Hansson, Nils Henrik Stubkjaer (författare)
- Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.
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- Tolbod, Lars Poulsen (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Kim, Won Yong (författare)
- Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.
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- Jakobsen, Steen (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Bouchelouche, Kirsten (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Wiggers, Henrik (författare)
- Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.
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- Frokiaer, Jorgen (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi,Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark. Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark. (creator_code:org_t)
- 2016-04-28
- 2016
- Engelska.
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Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 57:9, s. 1382-1387
- Relaterad länk:
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http://jnm.snmjourna...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Dynamic cardiac PET is used to quantify molecular processes in vivo. However, measurements of left ventricular (LV) mass and volume require electrocardiogram-gated PET data. The aim of this study was to explore the feasibility of measuring LV geometry using nongated dynamic cardiac PET. Methods: Thirty-five patients with aortic-valve stenosis and 10 healthy controls underwent a 27-min C-11-acetate PET/CT scan and cardiac MRI (CMR). The controls were scanned twice to assess repeatability. Parametric images of uptake rate K-1 and the blood pool were generated from nongated dynamic data. Using software-based structure recognition, the LV wall was automatically segmented from K-1 images to derive functional assessments of LV mass (m(LV)) and wall thickness. End systolic and end-diastolic volumes were calculated using blood pool images and applied to obtain stroke volume and LV ejection fraction (LVEF). PET measurements were compared with CMR. Results: High, linear correlations were found for LV mass (r = 0.95), end-systolic volume (r = 0.93), and end-diastolic volume (r = 0.90), and slightly lower correlations were found for stroke volume (r = 0.74), LVEF (r = 0.81), and thickness (r = 0.78). Bland Altman analyses showed significant differences for m(LV) and thickness only and an overestimation for LVEF at lower values. Intra- and interobserver correlations were greater than 0.95 for all PET measurements. PET repeatability accuracy in the controls was comparable to CMR. Conclusion: LV mass and volume are accurately and automatically generated from dynamic C-11-acetate PET without electrocardiogram gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- dynamic PET
- stroke volume
- myocardial mass
- C-11-acetate
- ejection fraction
- myocardial Wall thickness
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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