Neonatal outcomes in pregnancies resulting from oocyte donation: a cohort study in Sweden

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Elenis, Evangelia,1983-Uppsala universitet,Obstetrik & gynekologi,Uppsala University, Sweden (author)

Neonatal outcomes in pregnancies resulting from oocyte donation : a cohort study in Sweden

Article/chapterEnglish2016

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2016-10-21
Springer Science and Business Media LLC,2016
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-305848
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-305848URI
https://doi.org/10.1186/s12887-016-0708-5DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189362URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132517URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134389084URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies|Merck Serono; Family Planning Fond in Uppsala; Swedish Research Council for Health, Working Life and Welfare
Background: Pregnancies resulting through oocyte doantion have been associated with increased risk for adverse outcomes for the mother, such as gestational hypertensive disorders. However, little is known about possible neonatal complications of such pregnancies. The purpose of this study was to evaluate the neonatal health outcomes among singleton pregnancies in a population of relatively young and healthy oocyte recipients in Sweden, taking into account the medical indication leading to treatment.Methods: This cohort study involved 76 women conceiving with donated oocytes, 149 age-matched nulliparous women conceiving spontaneously and 63 women conceiving after non-donor IVF. Participants were recruited during 2005-2008 and followed up until delivery. Data on neonatal outcomes were retrieved from the National Birth Medical Register and the medical records of oocyte recipients from seven Swedish University Hospitals with IVF clinics. Logistic regression analyses were performed to examine the association of mode of conception and neonatal outcomes, adjusted for maternal age and BMI, gestational age and delivery by cesarean section.Results: Infants conceived through oocyte donation had higher odds for premature delivery( OR 2.36, 95%CI(1.02-5.45)), for being small for gestational age (OR 4.23, 95%CI(1.03-17.42)), and having Apgar score below 7 at 5 min(OR 10.57, 95%CI(1.21-92.20)) compared to spontaneously conceived infants. Similar trends were observed when comparing infants conceived through oocyte donatiion to those conceived by traditional IVF. Furthermore, donor oocyte infants had a lower mean birthweight and length compared to autologous oocyte neonates (p=0.0013); however, no differences were noted among infants born at term. Neonatal outcomes were more favorable among women with diminished ovarian reserve compared to those with other indications for oocyte donation.Conclusions: Infants conceived after oocyte donation in Sweden have higher odds of being born prematurely and having lower mean birthweight in comparison to non-donor infants. It seems that these unfavorable neonatal outcomes are present despite the age, weight and health restrictions applied to recipients before oocyte donation treatment in Sweden.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Donor conception
indication for oocyte donation
IVF
neonatal morbidity
neonatal outcomes
newborns
oocyte donation.
Pediatrics
Pediatrik

Added entries (persons, corporate bodies, meetings, titles ...)

Sydsjö, GunillaLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US,Obstetrics and Gynecology, Department of Clinical and Exprerimental Medicine, Faculty of Health Sciences, Linköping University(Swepub:liu)gunsy68 (author)
Skalkidou, Alkistis,1977-Uppsala universitet,Obstetrik & gynekologi,Uppsala University, Sweden(Swepub:uu)alksk607 (author)
Lampic, ClaudiaKarolinska Institutet(Swepub:umu)clla0025 (author)
Skoog Svanberg, Agneta,1958-Uppsala universitet,Obstetrik & gynekologi,Uppsala University, Sweden(Swepub:uu)agssv172 (author)
Uppsala universitetObstetrik & gynekologi (creator_code:org_t)

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In:BMC Pediatrics: Springer Science and Business Media LLC161471-2431

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