Atlantic salmon populations reveal adaptive divergence of immune related genes - a duplicated genome under selection

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-305938" > Atlantic salmon pop...

1 of 1
Previous record
Next record
To hitlist

Atlantic salmon populations reveal adaptive divergence of immune related genes - a duplicated genome under selection

Kjaerner-Semb, Erik (author): Inst Marine Res, Bergen, Norway.;Univ Bergen, Dept Biol, Bergen, Norway.

Ayllon, Fernando (author): Inst Marine Res, Bergen, Norway.

Furmanek, Tomasz (author): Inst Marine Res, Bergen, Norway.

Wennevik, Vidar (author): Inst Marine Res, Bergen, Norway.

Dahle, Geir (author): Inst Marine Res, Bergen, Norway.

Niemela, Eero (author): Nat Resources Inst Finland, Helsinki, Finland.

Ozerov, Mikhail (author): Univ Turku, Kevo Subarctic Res Inst, Turku, Finland.

Vaha, Juha-Pekka (author): Univ Turku, Kevo Subarctic Res Inst, Turku, Finland.;Assoc Water & Environm Western Uusimaa, Uusimaa, Finland.

Glover, Kevin A. (author): Inst Marine Res, Bergen, Norway.;Univ Bergen, Dept Biol, Bergen, Norway.

Rubin, Carl-Johan (author): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi

Wargelius, Anna (author): Inst Marine Res, Bergen, Norway.

Edvardsen, Rolf B. (author): Inst Marine Res, Bergen, Norway.

show less...

Inst Marine Res, Bergen, Norway;Univ Bergen, Dept Biol, Bergen, Norway. Inst Marine Res, Bergen, Norway. (creator_code:org_t)

2016-08-11
2016
English.
In: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 17

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://bmcgenomics....; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Populations of Atlantic salmon display highly significant genetic differences with unresolved molecular basis. These differences may result from separate postglacial colonization patterns, diversifying natural selection and adaptation, or a combination. Adaptation could be influenced or even facilitated by the recent whole genome duplication in the salmonid lineage which resulted in a partly tetraploid species with duplicated genes and regions. Results: In order to elucidate the genes and genomic regions underlying the genetic differences, we conducted a genome wide association study using whole genome resequencing data from eight populations from Northern and Southern Norway. From a total of similar to 4.5 million sequencing-derived SNPs, more than 10 % showed significant differentiation between populations from these two regions and ten selective sweeps on chromosomes 5, 10, 11, 13-15, 21, 24 and 25 were identified. These comprised 59 genes, of which 15 had one or more differentiated missense mutation. Our analysis showed that most sweeps have paralogous regions in the partially tetraploid genome, each lacking the high number of significant SNPs found in the sweeps. The most significant sweep was found on Chr 25 and carried several missense mutations in the antiviral mx genes, suggesting that these populations have experienced differing viral pressures. Interestingly the second most significant sweep, found on Chr 5, contains two genes involved in the NF-KB pathway (nkap and nkrf), which is also a known pathogen target that controls a large number of processes in animals. Conclusion: Our results show that natural selection acting on immune related genes has contributed to genetic divergence between salmon populations in Norway. The differences between populations may have been facilitated by the plasticity of the salmon genome. The observed signatures of selection in duplicated genomic regions suggest that the recently duplicated genome has provided raw material for evolutionary adaptation.

Subject headings

NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)

Keyword

Whole genome duplication
Adaptation
Aquaculture
Immune system
GWAS
Resequencing
Selective sweep
SNPs
Salmo salar

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

BMC Genomics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Kjaerner-Semb, E ...; Ayllon, Fernando; Furmanek, Tomasz; Wennevik, Vidar; Dahle, Geir; Niemela, Eero; show more...; Ozerov, Mikhail; Vaha, Juha-Pekka; Glover, Kevin A.; Rubin, Carl-Joha ...; Wargelius, Anna; Edvardsen, Rolf ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Genetics

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Microbiology

Articles in the publication: BMC Genomics

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se