High Maternal Body Mass Index in Early Pregnancy and Risks of Stillbirth and Infant Mortality-A Population-Based Sibling Study in Sweden

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MARC

Lindam, AnnaKarolinska Inst, Stockholm, Sweden. (author)

High Maternal Body Mass Index in Early Pregnancy and Risks of Stillbirth and Infant Mortality-A Population-Based Sibling Study in Sweden

Article/chapterEnglish2016

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2016-06-29
Oxford University Press (OUP),2016
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-305945
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-305945URI
https://doi.org/10.1093/aje/kww046DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134264328URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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In a population-based case-control study, we investigated whether familial confounding influenced the associations between maternal overweight/obesity and risks of stillbirth and infant mortality by including both population and sister controls. Using nationwide data from the Swedish Medical Birth Register (1992-2011), we included all primiparous women with singleton births who also had a sister with a first birth during that time period. We used logistic regression analyses to calculate odds ratios (and 95% confidence intervals) adjusted for maternal age, height, smoking habits, education, and time period (5-year groups) of child's birth. Body mass index (BMI) was calculated as weight (kg)/height (m)(2). Compared with population controls with a normal BMI (18.5-24.9), stillbirth risk increased with increasing BMI (BMI 25-29.9: odds ratio (OR) = 1.51 (95% confidence interval (CI): 1.21, 1.89); BMI 30-34.9: OR = 1.77 (95% CI: 1.24, 2.50); BMI a parts per thousand yen35: OR = 3.16 (95% CI: 2.10, 4.76)). The sister case-control analyses revealed similar results. Offspring of obese women (BMI a parts per thousand yen30) had an increased risk of infant mortality when population controls were used (OR = 2.41, 95% CI: 1.83, 3.16), and an even higher risk was obtained when sister controls were used (OR = 4.04, 95% CI: 2.25, 7.25). We conclude that obesity in early pregnancy is associated with increased risks of stillbirth and infant mortality independently of genetic and early environmental risk factors shared within families.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
body mass index
familial confounding
infant mortality
neonatal mortality
postneonatal mortality
sibling-design studies
stillbirth

Added entries (persons, corporate bodies, meetings, titles ...)

Johansson, StefanKarolinska Institutet (author)
Stephansson, OlofKarolinska Institutet (author)
Wikström, Anna-KarinKarolinska Institutet,Uppsala universitet,Obstetrik & gynekologi,Karolinska Inst, Stockholm, Sweden.(Swepub:uu)annwi179 (author)
Cnattingius, SvenKarolinska Institutet (author)
Karolinska InstitutetKarolinska Inst, Stockholm, Sweden. (creator_code:org_t)

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In:American Journal of Epidemiology: Oxford University Press (OUP)184:2, s. 98-1050002-92621476-6256

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