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  • Linnman, ClasHarvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Perioperat & Pain Med, Ctr Pain & Brain, Boston, MA USA. (author)

Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-09-22
  • Public Library of Science (PLoS),2016
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-306262
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306262URI
  • https://doi.org/10.1371/journal.pone.0161563DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134298374URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Substance P is released in painful and inflammatory conditions, affecting both peripheral processes and the central nervous system neurokinin 1 (NK1) receptor. There is a paucity of data on human brain alterations in NK1 expression, how this system may be affected by treatment, and interactions between central and peripheral tissue alterations. Ten subjects with chronic tennis elbow (lateral epicondylosis) were selected out of a larger (n = 120) randomized controlled trial evaluating graded exercise as a treatment for chronic tennis elbow (lateral epicondylosis). These ten subjects were examined by positron emission tomography (PET) with the NK1-specific radioligand 11C-GR205171 before, and eight patients were followed up after treatment with graded exercise. Brain binding in the ten patients before treatment, reflecting NK1-receptor availability (NK1-RA), was compared to that of 18 healthy subjects and, longitudinally, to the eight of the original ten patients that agreed to a second PET examination after treatment. Before treatment, patients had significantly lower NK1-RA in the insula, vmPFC, postcentral gyrus, anterior cingulate, caudate, putamen, amygdala and the midbrain but not the thalamus and cerebellum, with the largest difference in the insula contralateral to the injured elbow. No significant correlations between brain NK1-RA and pain, functional severity, or peripheral NK1-RA in the affected limb were observed. In the eight patients examined after treatment, pain ratings decreased in everyone, but there were no significant changes in NK1-RA. These findings indicate a role for the substance P (SP) / NK1 receptor system in musculoskeletal pain and tissue healing. As neither clinical parameters nor successful treatment response was reflected in brain NK1-RA after treatment, this may reflect the diverse function of the SP/NK1 system in CNS and peripheral tissue, or a change too small or slow to capture over the three-month treatment.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Catana, CiprianHarvard Med Sch, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Boston, MA USA. (author)
  • Svärdsudd, KurtUppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)kurtsvar (author)
  • Appel, LieuweUppsala universitet,Radiologi(Swepub:uu)lap02157 (author)
  • Engler, HenryUppsala universitet,Radiologi,Univ Republica, Uruguayan Ctr Mol Imaging CUDIM, Fac Med, Montevideo, Uruguay.;Univ Republica, Fac Sci, Montevideo, Uruguay.(Swepub:uu)henrengl (author)
  • Långström, BengtUppsala universitet,Radiologi,Organisk kemi,Imperial Coll, Fac Med, Neuropsychopharmacol Sect, London, England.(Swepub:uu)benglang (author)
  • Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore (author)
  • Furmark, TomasUppsala universitet,Institutionen för psykologi(Swepub:uu)tomafurm (author)
  • Fredrikson, MatsKarolinska Institutet(Swepub:uu)matsfred (author)
  • Borsook, DavidHarvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Perioperat & Pain Med, Ctr Pain & Brain, Boston, MA USA. (author)
  • Peterson, MagnusUppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)mapet227 (author)
  • Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Perioperat & Pain Med, Ctr Pain & Brain, Boston, MA USA.Harvard Med Sch, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Boston, MA USA. (creator_code:org_t)

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  • In:PLOS ONE: Public Library of Science (PLoS)11:91932-6203

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