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Reduced serotonin s...
Reduced serotonin synthesis and regional cerebral blood flow after anxiolytic treatment of social anxiety disorder
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- Frick, Andreas (author)
- Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Åhs, Fredrik (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden,Department of Psychology, Uppsala University, Uppsala, Sweden. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Appel, Lieuwe (author)
- Uppsala universitet,Radiologi,Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Jonasson, My (author)
- Uppsala universitet,Radiologi,Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Wahlstedt, Kurt (author)
- Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Bani, Massimo (author)
- GlaxoSmithKline, Verona, Italy
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- Pich, Emilio Merlo (author)
- GlaxoSmithKline, Verona, Italy
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- Bettica, Paolo (author)
- GlaxoSmithKline, Verona, Italy
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- Långström, Bengt (author)
- Uppsala universitet,Organisk kemi,Department of Chemistry, Uppsala University, Uppsala, Sweden
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi,Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Fredriksson, Mats (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Furmark, Tomas (author)
- Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 26:11, s. 1775-1783
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Abstract Social anxiety disorder (SAD) is associated with increased fear-related neural activity in the amygdala and we recently found enhanced serotonin synthesis rate in the same region. Anxiolytic agents like selective serotonin re-uptake inhibitors (SSRIs) and neurokinin-1 receptor (NK1R) antagonists reduce amygdala activity and may attenuate serotonin formation according to animal studies. Here, we examined the effects of SSRI pharmacotherapy, NK1R antagonism, and placebo on serotonin synthesis rate in relation to neural activity, measured as regional cerebral blood flow (rCBF), and symptom improvement in SAD. Eighteen SAD patients were randomized to receive daily double-blind treatment for six weeks either with the SSRI citalopram (n=6; 40 mg), the NK1R antagonist GR205171 (n=6; 5 mg; 4 weeks following 2 weeks of placebo), or placebo (n=6). Serotonin synthesis rate at rest and rCBF during stressful public speaking were assessed, before and after treatment, using positron emission tomography with the tracers [11C]5-hydroxytryptophan and [15O]water respectively. The Liebowitz Social Anxiety Scale (LSAS-SR) indexed symptom severity. All groups exhibited attenuated amygdala serotonin synthesis rate after treatment, which was associated with reduced amygdala rCBF during public speaking and accompanied by symptom improvement. These results are consistent with the notion that serotonin in the amygdala exerts an anxiogenic influence and, conversely, that anxiolysis is achieved through decreased serotonin formation in the amygdala.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Social phobia
- 5-HT
- NK1
- Positron emission tomography
- SSRI
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Frick, Andreas
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Åhs, Fredrik
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Appel, Lieuwe
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Jonasson, My
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Wahlstedt, Kurt
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Bani, Massimo
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show more...
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Pich, Emilio Mer ...
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Bettica, Paolo
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Långström, Bengt
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Lubberink, Mark
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Fredriksson, Mat ...
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Furmark, Tomas
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- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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European Neurops ...
- By the university
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Uppsala University
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Mid Sweden University
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Karolinska Institutet