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Sequence variation ...
Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients
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- Sclafani, Francesco (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Chau, Ian (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Cunningham, David (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Lampis, Andrea (author)
- Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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- Hahne, Jens Claus (author)
- Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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- Ghidini, Michele (author)
- Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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- Lote, Hazel (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.;Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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- Zito, Domenico (author)
- Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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- Tabernero, Josep (author)
- Univ Autonoma Barcelona, Vall Hebron Univ Hosp, Dept Med Oncol, Barcelona 08035, Spain.
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- Glimelius, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Cervantes, Andres (author)
- Univ Valencia, Biomed Res Inst INCLIVA, Dept Haematol & Med Oncol, Valencia 46010, Spain.
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- Begum, Ruwaida (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- De Castro, David Gonzalez (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Wilson, Sanna Hulkki (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Peckitt, Clare (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Eltahir, Zakaria (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Wotherspoon, Andrew (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Tait, Diana (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Brown, Gina (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Oates, Jacqueline (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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- Braconi, Chiara (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.;Inst Canc Res, Dept Canc Therapeut, Sutton SM2 5NG, Surrey, England.
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- Valeri, Nicola (author)
- Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.;Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England. (creator_code:org_t)
- 2016-07-05
- 2016
- English.
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In: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 37:9, s. 852-857
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Single nucleotide polymorphisms (SNPs) in microRNA genes have been associated with colorectal cancer (CRC) risk, survival and response to treatment. Conflicting results are available on the association between rs4919510, a SNP in mature miR-608 and clinical outcome in CRC. Here, we analyzed the association between rs4919510 and benefit from perioperative treatment in a randomised phase II trial of neoadjuvant Capecitabine and Oxaliplatin (CAPOX) followed by chemo-radiotherapy, surgery and adjuvant CAPOX +/- Cetuximab in high-risk locally advanced rectal cancer (LARC). A total of 155/164 (94.5%) patients were assessable. 95 (61.3%) were homozygous for CC, 55 (35.5%) heterozygous (CG) and 5 (3.2%) homozygous for GG. Median follow-up was 64.9 months. In the CAPOX arm the 5-year progression-free survival (PFS) and overall survival (OS) rates were 54.6% and 60.7% for CC and 82.0% and 82.1% for CG/GG, respectively (HR PFS 0.13, 95% CI: 0.12-0.83, P = 0.02; HR OS 0.38, 95% CI: 0.14-1.01, P = 0.05). In the CAPOX-C arm PFS and OS were 73.2 and 82.2%, respectively for CC carriers and 64.6 and 73.1% for CG/GG carriers (HR PFS 1.38, 95% CI: 0.61-3.13, P = 0.44; HR OS 1.34, 95% CI: 0.52-3.48, P = 0.55). An interaction was found between study treatment and rs4919510 genotype for both PFS (P = 0.02) and OS (P = 0.07). This is the first study investigating rs4919510 in LARC. The CC genotype appeared to be associated with worse prognosis compared to the CG/GG genotype in patients treated with chemotherapy and chemo-radiotherapy alone. Addition of Cetuximab to chemotherapy and chemo-radiotherapy in CC carriers appeared to improve clinical outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Sclafani, France ...
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Chau, Ian
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Cunningham, Davi ...
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Lampis, Andrea
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Hahne, Jens Clau ...
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Ghidini, Michele
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show more...
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Lote, Hazel
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Zito, Domenico
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Tabernero, Josep
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Glimelius, Bengt
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Cervantes, Andre ...
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Begum, Ruwaida
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De Castro, David ...
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Wilson, Sanna Hu ...
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Peckitt, Clare
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Eltahir, Zakaria
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Wotherspoon, And ...
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Tait, Diana
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Brown, Gina
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Oates, Jacquelin ...
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Braconi, Chiara
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Valeri, Nicola
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Carcinogenesis
- By the university
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Uppsala University