Search: onr:"swepub:oai:DiVA.org:uu-307293" >
Sequence variation ...
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Sclafani, FrancescoRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
(author)
Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-07-05
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Oxford University Press (OUP),2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-307293
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-307293URI
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https://doi.org/10.1093/carcin/bgw073DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Single nucleotide polymorphisms (SNPs) in microRNA genes have been associated with colorectal cancer (CRC) risk, survival and response to treatment. Conflicting results are available on the association between rs4919510, a SNP in mature miR-608 and clinical outcome in CRC. Here, we analyzed the association between rs4919510 and benefit from perioperative treatment in a randomised phase II trial of neoadjuvant Capecitabine and Oxaliplatin (CAPOX) followed by chemo-radiotherapy, surgery and adjuvant CAPOX +/- Cetuximab in high-risk locally advanced rectal cancer (LARC). A total of 155/164 (94.5%) patients were assessable. 95 (61.3%) were homozygous for CC, 55 (35.5%) heterozygous (CG) and 5 (3.2%) homozygous for GG. Median follow-up was 64.9 months. In the CAPOX arm the 5-year progression-free survival (PFS) and overall survival (OS) rates were 54.6% and 60.7% for CC and 82.0% and 82.1% for CG/GG, respectively (HR PFS 0.13, 95% CI: 0.12-0.83, P = 0.02; HR OS 0.38, 95% CI: 0.14-1.01, P = 0.05). In the CAPOX-C arm PFS and OS were 73.2 and 82.2%, respectively for CC carriers and 64.6 and 73.1% for CG/GG carriers (HR PFS 1.38, 95% CI: 0.61-3.13, P = 0.44; HR OS 1.34, 95% CI: 0.52-3.48, P = 0.55). An interaction was found between study treatment and rs4919510 genotype for both PFS (P = 0.02) and OS (P = 0.07). This is the first study investigating rs4919510 in LARC. The CC genotype appeared to be associated with worse prognosis compared to the CG/GG genotype in patients treated with chemotherapy and chemo-radiotherapy alone. Addition of Cetuximab to chemotherapy and chemo-radiotherapy in CC carriers appeared to improve clinical outcome.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Chau, IanRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
(author)
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Cunningham, DavidRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
(author)
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Lampis, AndreaInst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
(author)
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Hahne, Jens ClausInst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
(author)
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Ghidini, MicheleInst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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Lote, HazelRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.;Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
(author)
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Zito, DomenicoInst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
(author)
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Tabernero, JosepUniv Autonoma Barcelona, Vall Hebron Univ Hosp, Dept Med Oncol, Barcelona 08035, Spain.
(author)
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Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim
(author)
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Cervantes, AndresUniv Valencia, Biomed Res Inst INCLIVA, Dept Haematol & Med Oncol, Valencia 46010, Spain.
(author)
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Begum, RuwaidaRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
(author)
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De Castro, David GonzalezRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
(author)
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Wilson, Sanna HulkkiRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
(author)
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Peckitt, ClareRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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Eltahir, ZakariaRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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Wotherspoon, AndrewRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
(author)
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Tait, DianaRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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Brown, GinaRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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Oates, JacquelineRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.
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Braconi, ChiaraRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.;Inst Canc Res, Dept Canc Therapeut, Sutton SM2 5NG, Surrey, England.
(author)
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Valeri, NicolaRoyal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.;Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
(author)
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Royal Marsden NHS Fdn Trust, Dept Med, Sutton SM2 5PT, Surrey, England.Inst Canc Res, Dept Mol Pathol, Sutton SM2 5NG, Surrey, England.
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In:Carcinogenesis: Oxford University Press (OUP)37:9, s. 852-8570143-33341460-2180
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Sclafani, France ...
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Chau, Ian
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Cunningham, Davi ...
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Lampis, Andrea
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Hahne, Jens Clau ...
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Ghidini, Michele
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Lote, Hazel
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Zito, Domenico
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Tabernero, Josep
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Glimelius, Bengt
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Cervantes, Andre ...
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Begum, Ruwaida
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De Castro, David ...
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Wilson, Sanna Hu ...
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Peckitt, Clare
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Eltahir, Zakaria
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Wotherspoon, And ...
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Tait, Diana
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Brown, Gina
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Oates, Jacquelin ...
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Braconi, Chiara
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Valeri, Nicola
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Carcinogenesis
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