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Lenalidomide-bendam...
Lenalidomide-bendamustine-rituximab in patients older than 65 years with untreated mantle cell lymphoma
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- Albertsson-Lindblad, Alexandra (author)
- Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden.
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- Kolstad, Arne (author)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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- Laurell, Anna (author)
- Univ Uppsala Hosp, Dept Oncol, Uppsala, Sweden.
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- Raty, Riikka (author)
- Helsinki Univ Hosp, Dept Hematol, Helsinki, Finland.
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- Gronbaek, Kirsten (author)
- Rigshosp, Dept Hematol, Copenhagen, Denmark.
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- Sundberg, Jan (author)
- Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden.
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- Pedersen, Lone Bredo (author)
- Rigshosp, Dept Hematol, Copenhagen, Denmark.
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- Ralfkiaer, Elisabeth (author)
- Rigshosp, Dept Pathol, Copenhagen, Denmark.
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- Karjalainen-Lindsberg, Marja-Liisa (author)
- Univ Helsinki, Cent Hosp, Dept Pathol, Helsinki, Finland.
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- Sundström, Christer (author)
- Uppsala universitet,Klinisk och experimentell patologi,Department of Pathology, Uppsala University Hospital, Uppsala, Sweden; and.,Rose-Marie Amini
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- Ehinger, Mats (author)
- Univ Lund Hosp, Dept Pathol Cytol, Lund, Sweden.
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- Geisler, Christian (author)
- Rigshosp, Dept Hematol, Copenhagen, Denmark.
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- Jerkeman, Mats (author)
- Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden.
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Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden Oslo Univ Hosp, Dept Oncol, Oslo, Norway. (creator_code:org_t)
- American Society of Hematology, 2016
- 2016
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 128:14, s. 1814-1820
- Related links:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- For elderly patients with mantle cell lymphoma (MCL), there is no defined standard therapy. In this multicenter, open-label phase 1/2 trial, we evaluated the addition of lenalidomide (LEN) to rituximab-bendamustine (R-B) as first-line treatment for elderly patients with MCL. Patients >65 years with untreated MCL, stages II-IV were eligible for inclusion. Primary end points were maximally tolerable dose (MTD) of LEN and progression-free survival (PFS). Patients received 6 cycles every four weeks of L-B-R (L D1-14, B 90 mg/m(2) IV, days 1-2 and R 375 mg/m(2) IV, day 1) followed by single LEN (days 1-21, every four weeks, cycles 7-13). Fifty-one patients (median age 71 years) were enrolled from 2009 to 2013. In phase 1, the MTD of LEN was defined as 10 mg in cycles 2 through 6, and omitted in cycle 1. After 6 cycles, the complete remission rate (CRR) was 64%, and 36% were MRD negative. At a median follow-up time of 31 months, median PFS was 42 months and 3-year overall survival was 73%. Infection was the most common nonhematologic grade 3 to 5 event and occurred in 21 (42%) patients. Opportunistic infections occurred in 3 patients: 2 Pneumocystis carinii pneumonia and 1 cytomegalovirus retinitis. Second primary malignancies (SPM) were observed in 8 patients (16%). LEN could safely be combined with R-B when added from the second cycle in patients with MCL, and was associated with a high rate of CR and molecular remission. However, we observed a high degree of severe infections and an unexpected high number of SPMs, which may limit its use. This trial is registered at www.Clinicaltrials.gov as #NCT00963534.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Albertsson-Lindb ...
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Kolstad, Arne
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Laurell, Anna
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Raty, Riikka
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Gronbaek, Kirste ...
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Sundberg, Jan
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Pedersen, Lone B ...
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Ralfkiaer, Elisa ...
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Karjalainen-Lind ...
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Sundström, Chris ...
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Ehinger, Mats
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Geisler, Christi ...
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Jerkeman, Mats
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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MEDICAL AND HEAL ...
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Blood
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Uppsala University