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Lithium hyaluronate...
Lithium hyaluronate hydrogels enhance osteogenesis in vitro and ex vivo
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- Yan, Hongji, 1986- (author)
- Uppsala universitet,Institutionen för kemi - Ångström,polymer chemistry
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Hulsart-Billström, Gry (author)
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Rekha, Tripathi (author)
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Stefanie, Inglis (author)
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Wang, Shujiang (author)
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Stoddart, Martin J. (author)
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Oreffo, Richard (author)
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Hilborn, Jöns (author)
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Varghese, Oommen P. (author)
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
Close
- Lithium is a clinical drug for bipolar disorders and can enhance bone mass, promote osteogenesis of MSCs through inhibiting the Wnt/β-catenin signalling inhibitor GSK 3β. However, the systemic administration of lithium can trigger severe side-effects. Local administration has been attempted in the treatment of bone defects in animal models with positive outcomes. In this study, we explored a pre-manufactured hydrogel system containing the Li ion (Li-gel) in bone applications. Human MSCs cultured in this Li-gel exhibited enhanced osteogenic differentiation. Furthermore, this Li-gel was used to treat chick embryo chorioallantoic membrane (CAM) femur defects and enhanced the bone healing process.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Keyword
- Lithium
- mesenchymal stem cells
- bone morphogenetic protein
- CAM model.
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publication and Content Type
- pop (subject category)
- ovr (subject category)
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