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Post-mortem assessm...
Post-mortem assessment in vascular dementia : advances and aspirations
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- McAleese, Kirsty E. (author)
- Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England.
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- Alafuzoff, Irina (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Charidimou, Andreas (author)
- Harvard Med Sch, Massachusetts Gen Hosp Stroke Res Ctr, Dept Neurol, Hemorrhag Stroke Res Program, Boston, MA USA.
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- De Reuck, Jacques (author)
- Univ Hosp Lille, Stroke Res Team, Lille, France.
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- Grinberg, Lea T. (author)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.;Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA.;Univ Sao Paulo, Sch Med, Dept Pathol LIM 22, Sao Paulo, Brazil.
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- Hainsworth, Atticus H. (author)
- St Georges Univ London, Inst Cardiovasc & Cell Sci, London, England.
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- Hortobagyi, Tibor (author)
- Univ Debrecen, Dept Neuropathol, Debrecen, Hungary.
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- Ince, Paul (author)
- Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England.
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- Jellinger, Kurt (author)
- Inst Clin Neurobiol, Vienna, Austria.
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- Gao, Jing (author)
- Beijing Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China.
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- Kalaria, Raj N. (author)
- Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England.
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- Kovacs, Gabor G. (author)
- Med Univ Vienna, Inst Neurol, Vienna, Austria.
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- Kovari, Eniko (author)
- Univ Geneva, Dept Mental Hlth & Psychiat, Geneva, Switzerland.
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- Love, Seth (author)
- Univ Bristol, Clin Neurosci, Bristol, Avon, England.
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- Popovic, Mara (author)
- Univ Ljubljana, Inst Pathol, Fac Med, Ljubljana, Slovenia.
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- Skrobot, Olivia (author)
- Univ Bristol, Clin Neurosci, Bristol, Avon, England.
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- Taipa, Ricardo (author)
- Univ Porto, Ctr Hosp Porto, Unit Neuropathol, Oporto, Portugal.
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- Thal, Dietmar R. (author)
- Katholieke Univ Leuven, Dept Neurosci, Leuven, Belgium.;UZ Leuven, Dept Pathol, Leuven, Belgium.
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- Werring, David (author)
- UCL, Inst Neurol, London, England.
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- Wharton, Stephen B. (author)
- Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England.
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- Attems, Johannes (author)
- Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England.
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Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England Institutionen för immunologi, genetik och patologi (creator_code:org_t)
- 2016-08-26
- 2016
- English.
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In: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 14
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://bmcmedicine....
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Abstract
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- Background: Cerebrovascular lesions are a frequent finding in the elderly population. However, the impact of these lesions on cognitive performance, the prevalence of vascular dementia, and the pathophysiology behind characteristic in vivo imaging findings are subject to controversy. Moreover, there are no standardised criteria for the neuropathological assessment of cerebrovascular disease or its related lesions in human post-mortem brains, and conventional histological techniques may indeed be insufficient to fully reflect the consequences of cerebrovascular disease. Discussion: Here, we review and discuss both the neuropathological and in vivo imaging characteristics of cerebrovascular disease, prevalence rates of vascular dementia, and clinico-pathological correlations. We also discuss the frequent comorbidity of cerebrovascular pathology and Alzheimer's disease pathology, as well as the difficult and controversial issue of clinically differentiating between Alzheimer's disease, vascular dementia and mixed Alzheimer's disease/vascular dementia. Finally, we consider additional novel approaches to complement and enhance current post-mortem assessment of cerebral human tissue. Conclusion: Elucidation of the pathophysiology of cerebrovascular disease, clarification of characteristic findings of in vivo imaging and knowledge about the impact of combined pathologies are needed to improve the diagnostic accuracy of clinical diagnoses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Vascular dementia
- Vascular cognitive impairment
- Cerebrovascular disease
- Cerebrovascular lesions
- Neuropathology
- Magnetic resonance imaging
- Post-mortem MRI
- Mixed dementia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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McAleese, Kirsty ...
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Alafuzoff, Irina
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Charidimou, Andr ...
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De Reuck, Jacque ...
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Grinberg, Lea T.
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Hainsworth, Atti ...
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show more...
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Hortobagyi, Tibo ...
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Ince, Paul
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Jellinger, Kurt
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Gao, Jing
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Kalaria, Raj N.
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Kovacs, Gabor G.
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Kovari, Eniko
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Love, Seth
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Popovic, Mara
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Skrobot, Olivia
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Taipa, Ricardo
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Thal, Dietmar R.
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Werring, David
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Wharton, Stephen ...
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Attems, Johannes
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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BMC Medicine
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Uppsala University