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  • Franklin, Stanley S.Univ Calif Irvine, Sch Med, Div Cardiol, Heart Dis Prevent Program, Irvine, CA 92717 USA. (author)

The Cardiovascular Risk of White-Coat Hypertension

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-308892
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-308892URI
  • https://doi.org/10.1016/j.jacc.2016.08.035DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134506161URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND The role of white-coat hypertension (WCH) and the white-coat-effect (WCE) in development of cardiovascular disease (CVD) risk remains poorly understood. OBJECTIVES Using data from the population-based, 11-cohort IDACO (International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes), this study compared daytime ambulatory blood pressure monitoring with conventional blood pressure measurements in 653 untreated subjects with WCH and 653 normotensive control subjects. METHODS European Society Hypertension guidelines were used as a 5-stage risk score. Low risk was defined as 0 to 2 risk factors, and high risk was defined as >= 3 to 5 risk factors, diabetes, and/or history of prior CVD events. Age-and cohort-matching was done between 653 untreated subjects with WCH and 653 normotensive control subjects. RESULTS In a stepwise linear regression model, systolic WCE increased by 3.8 mm Hg (95% confidence interval [CI]: 3.1 to 4.6 mm Hg) per 10-year increase in age, and was similar in low-and high-risk subjects with or without prior CVD events. Over a median 10.6-year follow-up, incidence of new CVD events was higher in 159 high-risk subjects with WCH compared with 159 cohort-and age-matched high-risk normotensive subjects (adjusted hazard ratio [HR]: 2.06; 95% CI: 1.10 to 3.84; p = 0.023). The HR was not significant for 494 participants with low-risk WCH and age-matched low-risk normotensive subjects. Subgroup analysis by age showed that an association between WCH and incident CVD events is limited to older (age >= 60 years) high-risk WCH subjects; the adjusted HR was 2.19 (95% CI: 1.09 to 4.37; p = 0.027) in the older high-risk group and 0.88 (95% CI: 0.51 to 1.53; p = 0.66) in the older low-risk group (p for interaction = 0.044). CONCLUSIONS WCE size is related to aging, not to CVD risk. CVD risk in most persons with WCH is comparable to age-and risk-adjusted normotensive control subjects.

Subject headings and genre

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  • Thijs, LutgardeKatholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Leuven, Belgium. (author)
  • Asayama, KeiTohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan.;Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan. (author)
  • Li, YanShanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Ctr Epidemiol Studies & Clin Trials, Shanghai, Peoples R China.;Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Ctr Vasc Evaluat, Shanghai, Peoples R China. (author)
  • Hansen, Tine W.Gentofte & Res Ctr Prevent & Hlth, Steno Diabet Ctr, Gentofte, Denmark. (author)
  • Boggia, JoseUniv Republica, Hosp Clin, Ctr Nefrol, Montevideo, Uruguay.;Univ Republica, Hosp Clin, Dept Fisiopatol, Montevideo, Uruguay. (author)
  • Jacobs, LotteKatholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Leuven, Belgium. (author)
  • Zhang, ZhenyuKatholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Leuven, Belgium. (author)
  • Kikuya, MasahiroTohoku Univ, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi, Japan. (author)
  • Björklund-Bodegård, KristinaUppsala universitet,Geriatrik,Karolinska Inst, Danderyd Hosp, Dept Cardiol, Stockholm, Sweden.(Swepub:uu)krisbjor (author)
  • Ohkubo, TakayoshiTohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan.;Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi, Japan. (author)
  • Yang, Wen-YiKatholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Leuven, Belgium. (author)
  • Jeppesen, JorgenUniv Copenhagen, Glostrup Hosp, Dept Med, Copenhagen, Denmark. (author)
  • Dolan, EamonAddenbrooks Hosp, Cambridge Univ Hosp, Cambridge, England. (author)
  • Kuznetsova, TatianaInst Internal Med, Novosibirsk, Russia. (author)
  • Stolarz-Skrzypek, KatarzynaJagiellonian Univ, Coll Med, Dept Cardiol Intervent Elect & Hypertens 1, Krakow, Poland. (author)
  • Tikhonoff, ValerieUniv Padua, Dept Med, Padua, Italy. (author)
  • Malyutina, SofiaInst Internal Med, Novosibirsk, Russia. (author)
  • Casiglia, EdoardoUniv Padua, Dept Med, Padua, Italy. (author)
  • Nikitin, YuriInst Internal Med, Novosibirsk, Russia. (author)
  • Lind, LarsUppsala universitet,Geriatrik(Swepub:uu)larslind (author)
  • Sandoya, EdgardoAsociac Espanola Primera Socorros Mutuos, Montevideo, Uruguay. (author)
  • Kawecka-Jaszcz, KalinaJagiellonian Univ, Coll Med, Dept Cardiol Intervent Elect & Hypertens 1, Krakow, Poland. (author)
  • Filipovsky, JanCharles Univ Prague, Fac Med, Plzen, Czech Republic. (author)
  • Imai, YutakaTohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan.;Univ Republica, Hosp Clin, Ctr Nefrol, Montevideo, Uruguay.;Univ Republica, Hosp Clin, Dept Fisiopatol, Montevideo, Uruguay. (author)
  • Wang, Ji-GuangTohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan. (author)
  • O'Brien, EoinUniv Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin, Ireland. (author)
  • Staessen, Jan A.Katholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Leuven, Belgium.;Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands. (author)
  • Univ Calif Irvine, Sch Med, Div Cardiol, Heart Dis Prevent Program, Irvine, CA 92717 USA.Katholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Leuven, Belgium. (creator_code:org_t)

Related titles

  • In:Journal of the American College of Cardiology: Elsevier BV68:19, s. 2033-20430735-10971558-3597

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