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15-year follow-up o...
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Eskelund, Christian W.Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
15-year follow-up of the Second Nordic Mantle Cell Lymphoma trial (MCL2) : prolonged remissions without survival plateau
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-07-05
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Wiley,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-308900
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-308900URI
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https://doi.org/10.1111/bjh.14241DOI
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https://lup.lub.lu.se/record/03cf2745-80c5-488b-810b-5646c7f75750URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134485352URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In recent decades, the prognosis of Mantle Cell Lymphoma (MCL) has been significantly improved by intensified first-line regimens containing cytarabine, rituximab and consolidation with high-dose-therapy and autologous stem cell transplantation. One such strategy is the Nordic MCL2 regimen, developed by the Nordic Lymphoma Group. We here present the 15-year updated results of the Nordic MCL2 study after a median follow-up of 114years: For all patients on an intent-to-treat basis, the median overall and progression-free survival was 127 and 85years, respectively. The MCL International Prognostic Index (MIPI), biological MIPI, including Ki67 expression (MIPI-B) and the MIPI-B including mIR-18b expression (MIPI-B-miR), in particular, significantly divided patients into distinct risk groups. Despite very long response durations of the low and intermediate risk groups, we observed a continuous pattern of relapse and the survival curves never reached a plateau. In conclusion, despite half of the patients being still alive and 40% in first remission after more than 12years, we still see an excess disease-related mortality, even among patients experiencing long remissions. Even though we consider the Nordic regimen as a very good choice of regimen, we recommend inclusion in prospective studies to explore the benefit of novel agents in the frontline treatment of MCL.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kolstad, ArneOslo Univ Hosp, Dept Oncol, Oslo, Norway.,Oslo university hospital
(author)
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Jerkeman, MatsLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)onk-mje
(author)
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Raty, RiikkaUniv Helsinki, Dept Haematol, Cent Hosp, Helsinki, Finland.,Helsinki University Central Hospital
(author)
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Laurell, AnnaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Uppsala University Hospital(Swepub:lu)onk-ala
(author)
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Eloranta, SandraKarolinska Institutet,Karolinska Institute
(author)
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Smedby, Karin E.Karolinska Institutet,Karolinska Institute,Helsinki University Central Hospital
(author)
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Husby, SimonRigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
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Pedersen, Lone B.Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
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Andersen, Niels S.Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
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Eriksson, MikaelLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)onk-mer
(author)
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Kimby, EvaKarolinska Institutet,Karolinska Institute
(author)
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Bentzen, HansAarhus Univ Hosp, Dept Haematol, Aarhus, Denmark.,Aarhus University Hospital
(author)
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Kuittinen, OutiOulu Univ Hosp, Dept Radiotherapy & Oncol, Oulu, Finland.,Oulu University Hospital
(author)
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Lauritzsen, Grete F.Oslo Univ Hosp, Dept Oncol, Oslo, Norway.,Oslo university hospital
(author)
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Nilsson-Ehle, HermanSahlgrens Univ Hosp, Sect Haematol & Coagulat Med, Gothenburg, Sweden.,Sahlgrenska University Hospital
(author)
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Ralfkiaer, ElisabethRigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
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Ehinger, MatsLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)efor-meh
(author)
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Sundström, ChristerUppsala universitet,Klinisk och experimentell patologi,Univ Uppsala Hosp, Dept Genet & Pathol, Uppsala, Sweden.,Rose-Marie Amini,Uppsala University Hospital(Swepub:uu)chrisund
(author)
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Delabie, JanOslo Univ Hosp, Dept Pathol, Oslo, Norway.,Oslo university hospital
(author)
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Karjalainen-Lindsberg, Marja-LiisaUniv Helsinki, Dept Pathol, Cent Hosp, Helsinki, Finland.,Helsinki University Central Hospital
(author)
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Workman, Christopher T.Tech Univ Denmark, Dept Syst Biol, Lyngby, Denmark.;Univ Copenhagen, Dept Hlth Sci, Copenhagen, Denmark.,University of Copenhagen
(author)
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Garde, ChristianTech Univ Denmark, Dept Syst Biol, Lyngby, Denmark.;Univ Copenhagen, Dept Hlth Sci, Copenhagen, Denmark.,University of Copenhagen
(author)
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Elonen, ErkkiUniv Helsinki, Dept Haematol, Cent Hosp, Helsinki, Finland.
(author)
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Brown, PeterRigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
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Gronbaek, KirstenRigshosp, Dept Haematol, Copenhagen, Denmark.
(author)
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Geisler, Christian H.Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
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Grønbæk, KirstenCopenhagen University Hospital
(author)
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Rigshosp, Dept Haematol, Copenhagen, Denmark.Copenhagen University Hospital
(creator_code:org_t)
Related titles
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In:British Journal of Haematology: Wiley175:3, s. 410-4180007-10481365-2141
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Eskelund, Christ ...
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Kolstad, Arne
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Jerkeman, Mats
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Raty, Riikka
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Laurell, Anna
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Eloranta, Sandra
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Smedby, Karin E.
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Husby, Simon
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Pedersen, Lone B ...
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Andersen, Niels ...
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Eriksson, Mikael
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Kimby, Eva
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Bentzen, Hans
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Kuittinen, Outi
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Lauritzsen, Gret ...
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Nilsson-Ehle, He ...
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Ralfkiaer, Elisa ...
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Ehinger, Mats
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Sundström, Chris ...
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Delabie, Jan
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Karjalainen-Lind ...
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Workman, Christo ...
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Garde, Christian
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Elonen, Erkki
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Brown, Peter
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Gronbaek, Kirste ...
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Geisler, Christi ...
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Grønbæk, Kirsten
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and Hematology
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Uppsala University
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Lund University
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Karolinska Institutet