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Profiling cancer te...
Profiling cancer testis antigens in non-small-cell lung cancer
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- Djureinovic, Dijana (author)
- Uppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén, Patrick Micke
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- Hallström, Björn M. (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
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- Horie, Masafumi (author)
- Univ Tokyo, Grad Sch Med, Dept Resp Med, Tokyo, Japan.
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- Mattsson, Johanna Sofia Margareta, 1985- (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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- La Fleur, Linnea (author)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
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- Fagerberg, Linn (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
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- Brunnström, Hans (author)
- Reg Labs Reg Skane, Dept Pathol, Lund, Sweden.
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- Lindskog, Cecilia (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Madjar, Katrin (author)
- Tech Univ Dortmund, Dept Stat, Dortmund, Germany.
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- Rahnenfuehrer, Joerg (author)
- Tech Univ Dortmund, Dept Stat, Dortmund, Germany.
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- Ekman, Simon (author)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi
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- Ståhle, Elisabeth (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Koyi, Hirsh (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Gävleborg
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- Brandén, Eva (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg
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- Edlund, Karolina (author)
- Tech Univ Dortmund, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany.
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- Hengstler, Jan G. (author)
- Tech Univ Dortmund, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany.
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- Lambe, Mats (author)
- Karolinska Institutet
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- Saito, Akira (author)
- Univ Tokyo, Grad Sch Med, Dept Resp Med, Tokyo, Japan.
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- Botling, Johan (author)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
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- Ponten, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén
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- Uhlén, Mathias (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
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- Micke, Patrick (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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(creator_code:org_t)
- American Society for Clinical Investigation, 2016
- 2016
- English.
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In: JCI INSIGHT. - : American Society for Clinical Investigation. - 2379-3708. ; 1:10
- Related links:
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http://insight.jci.o...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets for immunotherapy. To comprehensively characterize the CTA landscape of non-small-cell lung cancer (NSCLC), we compared RNAseq data from 199 NSCLC tissues to the normal transcriptome of 142 samples from 32 different normal organs. Of 232 CTAs currently annotated in the Caner Testis Database (CTdatabase), 96 were confirmed in NSCLC. To obtain an unbiased CTA profile of NSCLC, we applied stringent criteria on our RNAseq data set and defined 90 genes as CTAs, of which 55 genes were not annotated in the CTdatabase, thus representing potential new CTAs. Cluster analysis revealed that CTA expression is histology dependent and concurrent expression is common. IHC confirmed tissue-specific protein expression of selected new CTAs (TKTL1, TGIF2LX, VCX, and CXORF67). Furthermore, methylation was identified as a regulatory mechanism of CTA expression based on independent data from The Cancer Genome Atlas. The proposed prognostic impact of CTAs in lung cancer was not confirmed, neither in our RNAseq cohort nor in an independent meta-analysis of 1,117 NSCLC cases. In summary, we defined a set of 90 reliable CTAs, including information on protein expression, methylation, and survival association. The detailed RNAseq catalog can guide biomarker studies and efforts to identify targets for immunotherapeutic strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Djureinovic, Dij ...
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Hallström, Björn ...
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Horie, Masafumi
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Mattsson, Johann ...
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La Fleur, Linnea
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Fagerberg, Linn
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show more...
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Brunnström, Hans
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Lindskog, Cecili ...
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Madjar, Katrin
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Rahnenfuehrer, J ...
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Ekman, Simon
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Ståhle, Elisabet ...
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Koyi, Hirsh
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Brandén, Eva
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Edlund, Karolina
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Hengstler, Jan G ...
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Lambe, Mats
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Saito, Akira
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Botling, Johan
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Ponten, Fredrik
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Uhlén, Mathias
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Micke, Patrick
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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JCI INSIGHT
- By the university
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Uppsala University
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Royal Institute of Technology
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Karolinska Institutet