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Multimodal analysis...
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Luikku, Antti J.Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.
(author)
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-10-14
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Springer Science and Business Media LLC,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-310733
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310733URI
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https://doi.org/10.1007/s00701-016-2980-4DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Optimal selection of idiopathic normal pressure hydrocephalus (iNPH) patients for shunt surgery is challenging. Disease State Index (DSI) is a statistical method that merges multimodal data to assist clinical decision-making. It has previously been shown to be useful in predicting progression in mild cognitive impairment and differentiating Alzheimer's disease (AD) and frontotemporal dementia. In this study, we use the DSI method to predict shunt surgery response for patients with iNPH. In this retrospective cohort study, a total of 284 patients (230 shunt responders and 54 non-responders) from the Kuopio NPH registry were analyzed with the DSI. Analysis included data from patients' memory disorder assessments, age, clinical symptoms, comorbidities, medications, frontal cortical biopsy, CT/MRI imaging (visual scoring of disproportion between Sylvian and suprasylvian subarachnoid spaces, atrophy of medial temporal lobe, superior medial subarachnoid spaces), APOE genotyping, CSF AD biomarkers, and intracranial pressure. Our analysis showed that shunt responders cannot be differentiated from non-responders reliably even with the large dataset available (AUC = 0.58). Prediction of the treatment response in iNPH is challenging even with our extensive dataset and refined analysis. Further research of biomarkers and indicators predicting shunt responsiveness is still needed.
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Hall, AnetteUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.
(author)
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Nerg, OssiUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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Koivisto, Anne M.Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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Hiltunen, MikkoUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Univ Eastern Finland, Inst Biomed, Kuopio, Finland.
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Helisalmi, SeppoUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.
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Herukka, Sanna-KaisaUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
(author)
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Sutela, AnnaKuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
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Kojoukhova, MariaKuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.;Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
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Mattila, JussiVTT Tech Res Ctr Finland, Tampere, Finland.;Combinostics Ltd, Tampere, Finland.
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Lotjonen, JyrkiVTT Tech Res Ctr Finland, Tampere, Finland.;Combinostics Ltd, Tampere, Finland.
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Rummukainen, JaanaKuopio Univ Hosp, Dept Pathol, Kuopio, Finland.
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Alafuzoff, IrinaUppsala universitet,Experimentell och klinisk onkologi,Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Univ Uppsala Hosp, Dept Pathol & Cytol, Uppsala, Sweden.(Swepub:uu)irial548
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Jaaskelainen, Juha E.Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.
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Remes, Anne M.Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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Soininen, HilkkaUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
(author)
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Leinonen, VilleKuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.
(author)
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Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.
(creator_code:org_t)
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In:Acta Neurochirurgica: Springer Science and Business Media LLC158:12, s. 2311-23190001-62680942-0940
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Luikku, Antti J.
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Hall, Anette
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Nerg, Ossi
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Koivisto, Anne M ...
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Hiltunen, Mikko
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Helisalmi, Seppo
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Herukka, Sanna-K ...
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Sutela, Anna
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Kojoukhova, Mari ...
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Mattila, Jussi
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Lotjonen, Jyrki
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Rummukainen, Jaa ...
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Alafuzoff, Irina
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Jaaskelainen, Ju ...
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Remes, Anne M.
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Soininen, Hilkka
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Leinonen, Ville
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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MEDICAL AND HEAL ...
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and Neurology
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Uppsala University