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Increased striatal ...
Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese
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- Asser, Andres (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
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- Koks, Sulev (author)
- Univ Tartu, Dept Pathophysiol, Tartu, Estonia.
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- Snellman, Anniina (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
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- Haaparanta-Solin, Merja (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
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- Arponen, Eveliina (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
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- Gronroos, Tove (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
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- Nairismagi, Jaak (author)
- Tallinn Univ Technol, Inst Gene Technol, Tallinn, Estonia.
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- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi
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- Soomets, Ursel (author)
- Univ Tartu, Dept Biochem, Tartu, Estonia.
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- Piip, Piret (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
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- Eltermaa, Mall (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
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- Sauk, Martin (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
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- Lindmae, Hanna (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
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- Rinne, Juha O. (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Dept Neurol, Turku, Finland.
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- Taba, Pille (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
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Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia Univ Tartu, Dept Pathophysiol, Tartu, Estonia. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Brain Research. - : Elsevier BV. - 0006-8993 .- 1872-6240. ; 1652, s. 97-102
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Intravenous use of a psychostimulant drug containing methcathinone (ephedrone) and manganese causes an irreversible extrapyramidal syndrome in drug abusers. We aimed to reproduce the syndrome in mice to evaluate dopaminergic damage. C57/B6 mice were intraperitoneally injected once a day with the study drug or saline for a period of 27 weeks. Motor activity was recorded in an automated motility-box. After 13 and 27 weeks of treatment, ex vivo digital autoradiography was performed using [C-11]dihydrotetrabenazine ([C-11]DTBZ). After 27 weeks of treatment [C-11]DTBZ autoradiography demonstrated a significant increase in the striatum to -cerebellum binding ratio compared with saline treated controls. At the same time point, there was no evident change in motor activity. Increased [C-11]DTBZ binding may indicate vesicular monoamine transporter type 2 (VMAT2) function is altered. The lack of extrapyramidal symptoms in animals could be attributed to low dosing regimen or high metabolic rate.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Manganism
- Ephedrone
- Methcathinone
- VMAT2
- PET
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Asser, Andres
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Koks, Sulev
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Snellman, Anniin ...
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Haaparanta-Solin ...
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Arponen, Eveliin ...
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Gronroos, Tove
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show more...
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Nairismagi, Jaak
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Bergquist, Jonas
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Soomets, Ursel
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Piip, Piret
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Eltermaa, Mall
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Sauk, Martin
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Lindmae, Hanna
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Rinne, Juha O.
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Taba, Pille
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Brain Research
- By the university
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Uppsala University